Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 14/20 | 0.45 |
| ▸ | PPARA | Q07869 | 12/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464979 | 0.89 | CYP1A2 (0.48) | PPARGPPARAMTNR1AMTNR1BCYP1A2 | |
| Ethylenediamine SCHEMBL29214558 | 0.83 | TAAR1 (0.42) | TAAR1PPARGPPARAMTNR1AMTNR1B | |
| SCHEMBL28451520 | 0.82 | PPARG (0.59) | PPARGPPARACYP1A2GAACYP2C9 | |
| SCHEMBL10436877 | 0.80 | TAAR1 (0.44) | TAAR1PPARGPPARAMTNR1AMTNR1B | |
| SCHEMBL10385266 | 0.79 | ALDH1A1 (0.47) | PPARGPPARAMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL9715374 | 0.78 | PPARA (0.45) | PPARGPPARAMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL28027915 | 0.78 | LMNA (0.43) | PPARGPPARAMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL17341898 | 0.78 | CYP1A2 (0.67) | PPARGPPARACYP1A2GAACYP2C9 | |
| SCHEMBL1628567 | 0.78 | GAA (0.47) | PPARGPPARAMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL7283885 | 0.77 | ALOX15 (0.52) | PPARGPPARAMTNR1AMTNR1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116535613-B | Preparation method of polyurethane curing agent | 江苏奥斯佳材料科技股份有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-116535612-B | Polyurethane curing agent | 江苏奥斯佳材料科技股份有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-116535613-A | Preparation method of polyurethane curing agent | 江苏奥斯佳材料科技股份有限公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-116535612-A | Polyurethane curing agent | 江苏奥斯佳材料科技股份有限公司 | 2023-08-04 | — | — | CN | disclosed |