Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | PGK2 | P07205 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MYLK | Q15746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949281 | 0.91 | ACHE (0.48) | ACHEMAPTALDH1A1POLBMEN1 | |
| SCHEMBL8256610 | 0.89 | PGK1 (0.39) | ACHEPGK1PGK2PARP10TACR1 | |
| Methoxymethane SCHEMBL27768340 | 0.86 | PGK1 (0.43) | ACHEPGK1PGK2MAPTALDH1A1 | |
| SCHEMBL23734489 | 0.84 | ACHE (0.61) | ACHEMAPTALDH1A1MEN1PRKCG | |
| SCHEMBL14949268 | 0.84 | ACHE (0.42) | ACHEMAPTALDH1A1MEN1PRKCG | |
| SCHEMBL1144911 | 0.84 | TACR1 (0.41) | PARP10TACR1ALDH1A1POLBIDO1 | |
| SCHEMBL501769 | 0.83 | PGK1 (0.48) | ACHEPGK1PGK2MAPTALDH1A1 | |
| SCHEMBL13376377 | 0.83 | ADRB2 (0.37) | ACHEPGK1PGK2TACR1POLB | |
| SCHEMBL19142118 | 0.83 | ACHE (0.41) | ACHEMAPTALDH1A1POLBMEN1 | |
| SCHEMBL1620230 | 0.81 | GRIN2D (0.47) | ACHEMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989194-B1 | CYCLIC SULFONES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2010-08-25 | — | — | EP | disclosed |
| US-20090099207-A1 | Cyclic sulfones useful as BACE inhibitors | RUEEGER HEINRICH | 2009-04-16 | — | — | US | disclosed |
| CN-101384580-A | Cyclic sulfones useful as BACE inhibitors | NOVARTIS AG (CH) | 2009-03-11 | — | — | CN | disclosed |
| EP-1989194-A1 | CYCLIC SULFONES USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007093621-A1 | CYCLIC SULFONES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099207-A1 | Cyclic sulfones useful as BACE inhibitors | BACE1, BACE2, APP | ACHE 352/4885PGK1 3393/4885PGK2 3742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.