SCHEMBL2904934

SCHEMBL2904934

O=c1oc(-c2cc(C(F)(F)F)nn2-c2ncccc2Cl)nc2c(O)cc(I)cc12

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ PTGS2 P35354 7/20 0.34
▸ PTGS1 P23219 3/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ DHODH Q02127 2/20 0.33
▸ CARM1 Q86X55 1/20 0.32
▸ NR3C2 P08235 1/20 0.31
▸ PDPK1 O15530 1/20 0.31
▸ RXRA P19793 2/20 0.30
▸ NR1H2 P55055 2/20 0.30
▸ NR1H3 Q13133 2/20 0.30
▸ PDE4D Q08499 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL950708 0.91 KDM4E (0.35) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL950989 0.90 KDM4E (0.34) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL950826 0.85 KDM4E (0.36) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL950425 0.85 KDM4E (0.37) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL12911874 0.85 KDM4E (0.33) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL535651 0.85 KDM4E (0.35) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL12911905 0.84 KDM4E (0.35) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL25235198 0.83 MAPT (0.35) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL951016 0.83 PDPK1 (0.36) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL950884 0.83 KDM4E (0.34) KDM4EMEN1ALDH1A1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1871760-B1 CYANO ANTHRANILAMIDE INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-08-11 — — EP disclosed
US-7601743-B2 Cyano anthranilamide insecticides SYNGENTA CROP PROTECTION, INC. (US) 2009-10-13 — — US disclosed
US-20080182750-A1 Cyano Anthranilamide Insecticides SYNGENTA CROP PROTECTION, INC. (US) 2008-07-31 — — US disclosed
EP-1871760-A1 CYANO ANTHRANILAMIDE INSECTICIDES Syngeta Participations AG (CH) 2008-01-02 — — EP disclosed
WO-2006111341-A1 CYANO ANTHRANILAMIDE INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2006-10-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080182750-A1 Cyano Anthranilamide Insecticides CRY1, CRYAA, ALDH7A1 KDM4E 2291/4885MEN1 1413/4885ALDH1A1 288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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