SCHEMBL950989

SCHEMBL950989

Cc1cc(I)cc2c(=O)oc(-c3cc(C(F)(F)F)nn3-c3ncccc3Cl)nc12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ DHODH Q02127 2/20 0.33
▸ ELANE P08246 1/20 0.33
▸ MAPT P10636 2/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ OPRL1 P41146 1/20 0.32
▸ RXRA P19793 2/20 0.32
▸ NR1H2 P55055 2/20 0.32
▸ NR1H3 Q13133 2/20 0.32
▸ PTGS2 P35354 2/20 0.32
▸ PARP4 Q9UKK3 1/20 0.32
▸ PTGS1 P23219 1/20 0.32
▸ CARM1 Q86X55 1/20 0.32
▸ CYP17A1 P05093 1/20 0.32
▸ CYP1A2 P05177 1/20 0.32
▸ NR3C2 P08235 2/20 0.31
▸ NR3C1 P04150 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL499517 0.92 KDM4E (0.34) KDM4EL3MBTL1DHODHELANEMAPT
SCHEMBL950884 0.92 KDM4E (0.34) KDM4EL3MBTL1DHODHELANEMAPT
SCHEMBL30466609 0.92 MAPT (0.35) KDM4EL3MBTL1DHODHELANEMAPT
SCHEMBL25235198 0.92 MAPT (0.35) KDM4EL3MBTL1DHODHELANEMAPT
Ammonia Solution, Strong SCHEMBL25275402 0.91 MAPT (0.35) KDM4EL3MBTL1DHODHELANEMAPT
SCHEMBL30466601 0.91 MAPT (0.35) KDM4EL3MBTL1DHODHELANEMAPT
SCHEMBL950708 0.91 KDM4E (0.35) KDM4EL3MBTL1DHODHMAPTMEN1
SCHEMBL951078 0.90 DHODH (0.34) KDM4EL3MBTL1DHODHELANEMAPT
SCHEMBL2904934 0.90 KDM4E (0.34) KDM4EL3MBTL1DHODHMAPTMEN1
SCHEMBL950940 0.89 ELANE (0.45) KDM4EL3MBTL1DHODHELANEMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9161540-B2 Cyano anthranilamide insecticides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-10-20 — — US disclosed
US-20130189228-A1 CYANO ANTHRANILAMIDE INSECTICIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2013-07-25 — — US disclosed
EP-2264022-B1 Cyano anthranilamide insecticides DU PONT (US) 2013-07-24 — — EP disclosed
US-8475819-B2 Cyano anthranilamide insecticides E I DU PONT DE NEMOURS AND COMPANY (US) 2013-07-02 — — US disclosed
EP-1599463-B1 CYANO ANTHRANILAMIDE INSECTICIDES DU PONT (US) 2013-06-05 — — EP disclosed
US-20110319452-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-12-29 — — US disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 — — EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7875634-B2 contain 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-pyrazole-5-carboxamide; for controlling invertebrate pests in both agronomic and nonagronomic environments E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-01-25 — — US disclosed
US-20070264299-A1 Cyano anthranilamide insecticides FMC CORPORATION 2007-11-15 — — US disclosed
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests FINKELSTEIN BRUCE L 2007-08-30 — — US disclosed
US-7247647-B2 Cyano anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-07-24 — — US disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 — — WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 — — WO disclosed
US-7199138-B2 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-04-03 — — US disclosed
US-20060111403-A1 Cyano anthranilamide insecticides FMC CORPORATION 2006-05-25 — — US disclosed
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY 2005-12-22 — — US disclosed
EP-1599463-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. du Pont de Nemours and Company (US) 2005-11-30 — — EP disclosed
WO-2004067528-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-08-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060111403-A1 Cyano anthranilamide insecticides C1S, C5, CBR3 KDM4E 1426/4885L3MBTL1 274/4885DHODH 1074/4885
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 KDM4E 1084/4885L3MBTL1 852/4885DHODH 771/4885
US-20110319452-A1 CYANO ANTHRANILAMIDE INSECTICIDES CBR3, C5, C1R KDM4E 857/4885L3MBTL1 139/4885DHODH 1187/4885
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 KDM4E 794/4885L3MBTL1 664/4885DHODH 2465/4885
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 KDM4E 834/4885L3MBTL1 654/4885DHODH 2433/4885
US-20130189228-A1 CYANO ANTHRANILAMIDE INSECTICIDES CBR3, C5, C1R KDM4E 857/4885L3MBTL1 139/4885DHODH 1187/4885
US-20070264299-A1 Cyano anthranilamide insecticides C1S, CBR3, C5 KDM4E 1048/4885L3MBTL1 108/4885DHODH 1499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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