Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | TACR3 | P29371 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905437 | 0.87 | MEN1 (0.34) | MEN1KMT2ATDP1TACR3KDM4E | |
| SCHEMBL2901695 | 0.81 | ALOX15 (0.36) | MEN1KMT2ASRCIDO1KDM4E | |
| SCHEMBL2904863 | 0.78 | CCR5 (0.34) | MEN1KMT2AKDM4E | |
| SCHEMBL2907439 | 0.74 | JAK2 (0.36) | MEN1KMT2ATDP1HTR7GBA1 | |
| SCHEMBL2908468 | 0.73 | ALDH1A1 (0.41) | MEN1KMT2A | |
| SCHEMBL2907391 | 0.73 | OPRM1 (0.50) | MEN1KMT2ATDP1MAP4K1KDM4E | |
| SCHEMBL2906133 | 0.70 | HSP90AA1 (0.43) | MEN1KMT2AKDM4E | |
| SCHEMBL11625109 | 0.70 | MBNL1 (0.47) | DCUN1D1TDP1HTR7ADORA2AMBNL1 | |
| SCHEMBL2902350 | 0.69 | TTK (0.35) | MEN1KMT2ATDP1SRCTACR3 | |
| SCHEMBL2905341 | 0.67 | CHRM2 (0.43) | MEN1KMT2ATDP1MAP4K1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611107-B1 | 1,3,4-SUBSTITUTED PYRAZOLES FOR USE AS 5-HT RECEPTOR ANTAGONISTS IN THE TREATMENT OF PSYCHOSES AND NEUROLOGICAL DISORDERS | MERCK PATENT GMBH (DE) | 2010-08-18 | — | — | EP | claimed |