Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905043 | 1.00 | APP (0.47) | APPGPR183HRH3ALDH1A1LMNA | |
| SCHEMBL2902873 | 0.85 | ALDH1A1 (0.60) | GPR183ALDH1A1LMNATP53RAB9A | |
| SCHEMBL2902877 | 0.85 | ALDH1A1 (0.60) | GPR183ALDH1A1LMNATP53RAB9A | |
| SCHEMBL2898842 | 0.84 | L3MBTL1 (0.53) | GPR183HRH3ALDH1A1LMNATP53 | |
| SCHEMBL2898840 | 0.84 | L3MBTL1 (0.53) | GPR183HRH3ALDH1A1LMNATP53 | |
| SCHEMBL2904962 | 0.83 | GPR183 (0.45) | GPR183HRH3ALDH1A1LMNATP53 | |
| SCHEMBL2904959 | 0.83 | GPR183 (0.45) | GPR183HRH3ALDH1A1LMNATP53 | |
| SCHEMBL2903699 | 0.82 | RAB9A (0.58) | GPR183ALDH1A1LMNAF2RCCR1 | |
| SCHEMBL2903702 | 0.82 | RAB9A (0.58) | GPR183ALDH1A1LMNAF2RCCR1 | |
| SCHEMBL2904919 | 0.79 | HPGD (0.65) | ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |