Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2900571 | 0.90 | ALDH1A3 (0.39) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2905527 | 0.81 | APP (0.43) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2901452 | 0.78 | NPC1 (0.47) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2810030 | 0.75 | APP (0.54) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2900566 | 0.73 | ALDH1A1 (0.40) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1727234 | 0.73 | NPC1 (0.69) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1727420 | 0.72 | NPC1 (0.50) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6491308 | 0.70 | ALDH1A3 (0.69) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1726360 | 0.70 | APP (0.56) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2901138 | 0.69 | ALDH1A3 (0.75) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2216050-A1 | UTILIZATION OF NOVEL COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF PRODUCING THE SAME | Nihon Medi-Physics Co., Ltd. (JP) | 2010-08-11 | — | — | EP | disclosed |