SCHEMBL2901138

SCHEMBL2901138

COc1ccc(-c2cn3cc(I)ccc3n2)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 6/20 0.75
NPC1 O15118 6/20 0.67
RAB9A P51151 6/20 0.67
KDM4E B2RXH2 5/20 0.67
PKM P14618 2/20 0.67
EPHX2 P34913 1/20 0.67
APP P05067 5/20 0.65
ALDH1A1 P00352 3/20 0.57
POLB P06746 2/20 0.57
GAA P10253 2/20 0.57
TLR9 Q9NR96 2/20 0.55
TLR7 Q9NYK1 2/20 0.55
SMN1; SMN2 Q16637 3/20 0.53
MEN1 O00255 1/20 0.53
MITF O75030 1/20 0.53
KDM5A P29375 1/20 0.53
KDM5C P41229 1/20 0.53
KMT2A Q03164 1/20 0.53
PAX8 Q06710 1/20 0.53
GLA P06280 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2899627 0.91 ALDH1A3 (0.70) ALDH1A3NPC1RAB9AKDM4EPKM
SCHEMBL15177306 0.85 APP (0.73) ALDH1A3NPC1RAB9AKDM4EPKM
SCHEMBL2932154 0.84 ALDH1A3 (0.79) ALDH1A3NPC1RAB9AKDM4EPKM
SCHEMBL1727234 0.84 NPC1 (0.69) ALDH1A3NPC1RAB9AKDM4EPKM
SCHEMBL24320031 0.84 NPC1 (0.74) ALDH1A3NPC1RAB9AKDM4EPKM
SCHEMBL12380446 0.82 ALDH1A3 (0.75) ALDH1A3NPC1RAB9AKDM4EPKM
SCHEMBL13217828 0.82 ALDH1A3 (0.75) ALDH1A3NPC1RAB9AKDM4EPKM
SCHEMBL13198289 0.82 ALDH1A3 (0.75) ALDH1A3NPC1RAB9AKDM4EPKM
SCHEMBL13325701 0.81 ALDH1A3 (0.74) ALDH1A3NPC1RAB9AKDM4EPKM
SCHEMBL13325773 0.81 ALDH1A3 (1.00) ALDH1A3NPC1RAB9AKDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070905-A1 Derivatives of Imidazo[1,2-A]Pyridine with Anti-Inflammatory Activity UNIV DE VELENCIA (ES) 2026-03-12 US claimed
WO-2025003545-A1 DERIVATIVES OF IMIDAZO[1,2-A]PYRIDINE WITH ANTI-INFLAMMATORY ACTIVITY UNIVERSITAT DE VALÈNCIA (ES) 2025-01-02 WO claimed
US-20100216994-A1 USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME NIHON MEDI-PHYSICS CO., LTD. (JP) 2010-08-26 US disclosed
US-20100216994-A1 USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME NIHON MEDI-PHYSICS CO., LTD. (JP) 2010-08-26 US disclosed
EP-2218464-A1 Compounds for non-invasive measurement of aggregates of amyloid peptides Technische Universität München (DE) 2010-08-18 EP disclosed
EP-2216052-A1 USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME Nihon Medi-Physics Co., Ltd. (JP) 2010-08-11 EP disclosed
EP-2216052-A1 USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME Nihon Medi-Physics Co., Ltd. (JP) 2010-08-11 EP disclosed
US-20090252680-A1 NOVEL COMPOUND WITH AFFINITY FOR AMYLOID NIHON- MEDI-PHYSICS CO., LTD (JP) 2009-10-08 US disclosed
US-20090252680-A1 NOVEL COMPOUND WITH AFFINITY FOR AMYLOID NIHON- MEDI-PHYSICS CO., LTD (JP) 2009-10-08 US disclosed
EP-2098523-A1 NOVEL COMPOUNDS WITH AFFINITY FOR AMYLOID NIHON MEDI-PHYSICS CO., LTD. (JP) 2009-09-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100216994-A1 USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME APBA1, APP, S100A4 ALDH1A3 2637/4885NPC1 792/4885RAB9A 2882/4885
US-20260070905-A1 Derivatives of Imidazo[1,2-A]Pyridine with Anti-Inflammatory Activity IL1A, IL6, IL1B ALDH1A3 709/4885NPC1 933/4885RAB9A 1534/4885
US-20090252680-A1 NOVEL COMPOUND WITH AFFINITY FOR AMYLOID APBA1, APP, SLC7A1 ALDH1A3 3051/4885NPC1 222/4885RAB9A 1766/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.