Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728195 | 0.95 | APP (0.53) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL796015 | 0.91 | APP (0.59) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1727344 | 0.87 | APP (0.62) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1727234 | 0.85 | NPC1 (0.69) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1727248 | 0.85 | RAB9A (0.48) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL2810030 | 0.82 | APP (0.54) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL15177306 | 0.81 | APP (0.73) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL2901138 | 0.80 | ALDH1A3 (0.75) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1727584 | 0.80 | HRH3 (0.49) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3627420 | 0.80 | TLR9 (0.54) | APPNPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8506930-B2 | Compounds having affinity for amyloid | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2013-08-13 | — | — | US | disclosed |
| US-8303935-B2 | Alkoxy substituted imidazo[1,2-a]pyridines having affinity for amyloid | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-20120271053-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2012-10-25 | — | — | US | disclosed |
| US-8207189-B2 | Compound having affinity for amyloid | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| US-8207189-B2 | Compound having affinity for amyloid | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| WO-2011029443-A8 | DEVICE FOR A MULTIPLE SOCKET FOR RECEIVING PLUG CONNECTIONS | HOHENADEL THORSTEN (DE) | 2012-05-10 | — | — | WO | disclosed |
| EP-2019103-B1 | COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDIPHYSICS CO LTD (JP) | 2011-11-30 | — | — | EP | disclosed |
| EP-2098522-B1 | COMPOUNDS HAVING AFFINITY FOR AMYLOID | NIHON MEDIPHYSICS CO LTD (JP) | 2011-10-19 | — | — | EP | disclosed |
| US-20100249419-A1 | UTILIZATION OF NOVEL COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF PRODUCING THE SAME | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2010-09-30 | — | — | US | disclosed |
| US-20100249419-A1 | UTILIZATION OF NOVEL COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF PRODUCING THE SAME | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2216050-A1 | UTILIZATION OF NOVEL COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF PRODUCING THE SAME | Nihon Medi-Physics Co., Ltd. (JP) | 2010-08-11 | — | — | EP | disclosed |
| US-20100069640-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDI-PHYSICS COL, LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
| US-20100069640-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDI-PHYSICS COL, LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
| US-20090252679-A1 | Novel Compound Having Affinity for Amyloid | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2009-10-08 | — | — | US | disclosed |
| EP-2098522-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2009-09-09 | — | — | EP | disclosed |
| EP-2098522-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2009-09-09 | — | — | EP | disclosed |
| EP-2019103-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2009-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069640-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | APP, APBA1, C1QBP | APP 1/4885NPC1 172/4885ALDH1A1 2065/4885 |
| US-20100249419-A1 | UTILIZATION OF NOVEL COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF PRODUCING THE SAME | APBA1, S100A4, APP | APP 3/4885NPC1 1367/4885ALDH1A1 956/4885 |
| US-20090252679-A1 | Novel Compound Having Affinity for Amyloid | APBA1, SAAL1, SLC43A1 | APP 4/4885NPC1 412/4885ALDH1A1 1324/4885 |
| US-20120271053-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | APBA1, SAAL1, SLC43A1 | APP 4/4885NPC1 412/4885ALDH1A1 1324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.