Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | KIF11 | P52732 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoromethylbenzene SCHEMBL28516552 | 0.90 | TSHR (0.78) | TSHRALDH1A1KIF11BACE1TRPV6 | |
| Trifluoromethylbenzene SCHEMBL28340462 | 0.90 | TSHR (0.78) | TSHRALDH1A1KIF11BACE1TRPV6 | |
| SCHEMBL28512559 | 0.87 | KIF11 (0.75) | TSHRALDH1A1KIF11BACE1TRPV6 | |
| SCHEMBL3626453 | 0.85 | TSHR (0.48) | TSHRALDH1A1KIF11BACE1PTPN1 | |
| Trifluoromethylbenzene SCHEMBL6154213 | 0.85 | TSHR (0.70) | TSHRALDH1A1KIF11BACE1TRPV6 | |
| Trifluoromethylbenzene SCHEMBL8692 | 0.84 | TSHR (1.00) | TSHRALDH1A1KIF11BACE1TRPV6 | |
| Trifluoromethylbenzene SCHEMBL27760126 | 0.84 | TSHR (1.00) | TSHRALDH1A1KIF11BACE1TRPV6 | |
| Trifluoromethylbenzene SCHEMBL175647 | 0.84 | TSHR (1.00) | TSHRALDH1A1KIF11BACE1TRPV6 | |
| SCHEMBL29129687 | 0.83 | TSHR (0.52) | TSHRALDH1A1RAB9ACA1CA2 | |
| SCHEMBL2258322 | 0.83 | TSHR (0.52) | TSHRALDH1A1RAB9ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122011331-A | Preparation method of high-hydrophobicity corrosion-resistant fluorine-containing polyurea material | 沈阳化工大学 | 2026-05-12 | — | — | CN | claimed |
| CN-116296668-A | Enantiomer of partially racemized chiral urea, preparation method, detection and application | 青岛科技大学 | 2023-06-23 | — | — | CN | claimed |
| CN-112940217-A | Shock-absorbing sole of sports shoe and preparation method thereof | 福建美明达鞋业发展有限公司 | 2021-06-11 | — | — | CN | claimed |
| EP-3403651-B1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | LANZHOU INST CHEMICAL PHYSICS CAS (CN) | 2019-10-30 | — | — | EP | claimed |
| CN-109642010-A | The synthetic method of poly- Oxazolidinone compound | 科思创德国股份有限公司 | 2019-04-16 | — | — | CN | claimed |
| US-20180334448-A1 | Isocorydine derivatives, preparation method and use thereof | LANZHOU INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) | 2018-11-22 | — | — | US | claimed |
| EP-3403651-A1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | Lanzhou Institute Of Chemical Physics Chinese Academy of Sciences (CN) | 2018-11-21 | — | — | EP | claimed |
| CN-122011331-A | Preparation method of high-hydrophobicity corrosion-resistant fluorine-containing polyurea material | 沈阳化工大学 | 2026-05-12 | — | — | CN | disclosed |
| CN-119019387-A | 3-Substituted-1-H-indole pyrazole derivative compound, and preparation method and application thereof | 贵州大学 | 2024-11-26 | — | — | CN | disclosed |
| CN-117903326-A | Polysaccharide derivative capable of being bonded by hot melting, preparation method and application thereof | 中国科学院化学研究所 | 2024-04-19 | — | — | CN | disclosed |
| CN-117551001-A | Preparation method and preparation system of substituted phenyl isocyanate | 湖南化工研究院有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-117510429-A | Compound containing methyl isoxazole structure, and preparation method and application thereof | 中国农业大学 | 2024-02-06 | — | — | CN | disclosed |
| CN-117343032-A | Method for preparing amide compound based on photocatalytic isocyanate | 中国科学技术大学 | 2024-01-05 | — | — | CN | disclosed |
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
| EP-1853557-A2 | 1,5-DIARYLPYRROLE DERIVATIVES, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2007-11-14 | — | — | EP | disclosed |
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007000505-A2 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2007-01-04 | — | — | WO | disclosed |
| WO-2006087476-A2 | 1,5-DIARYLPYRROLE DERIVATIVES, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2006-08-24 | — | — | WO | disclosed |
| US-6833476-B2 | Fluorinating a dichlorofluoromethyl or methoxy or a trichloromethyl or methoxybenzene isocyanate by reacting with HF to form the carbamoyl fluoride intermediate and forming a trifluoromethyl or methoxybenzene isocyanate | RHODIA CHIMIE (FR) | 2004-12-21 | — | — | US | disclosed |
| US-20040049069-A1 | Method for using a carbamoyl fluoride as fluorinating agent | RHODIA CHIMIE (FR) | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | PDE4A, PDE4B, BRAF | TSHR 1074/4885ALDH1A1 1662/4885KIF11 3194/4885 |
| US-20180334448-A1 | Isocorydine derivatives, preparation method and use thereof | CCND2, CCND3, IDH3A | TSHR 2078/4885ALDH1A1 4178/4885KIF11 3937/4885 |
| US-20040049069-A1 | Method for using a carbamoyl fluoride as fluorinating agent | CA7, CA6, CA3 | TSHR 400/4885ALDH1A1 4307/4885KIF11 1050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.