Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.38 |
| ▸ | PDE1A | P54750 | 3/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29071996 | 0.85 | PIK3R1 (0.46) | DCTPP1CASRP2RX4P2RX3PIK3R1 | |
| SCHEMBL13178171 | 0.84 | CCR2 (0.49) | DCTPP1CASRP2RX4P2RX3PIK3R1 | |
| SCHEMBL31283391 | 0.82 | PDE1B (0.40) | DCTPP1CASRP2RX4P2RX3PIK3R1 | |
| SCHEMBL29703944 | 0.78 | PIK3R1 (0.46) | DCTPP1CASRP2RX4P2RX3PIK3R1 | |
| SCHEMBL1572340 | 0.68 | MAPT (0.51) | MAPT | |
| SCHEMBL23723081 | 0.68 | PDE1B (0.61) | DCTPP1CASRP2RX4NPBWR1PIK3R1 | |
| SCHEMBL30944623 | 0.66 | SDHB (0.44) | NPBWR1PDE1BPDE1APDE1CMAPT | |
| SCHEMBL7414967 | 0.66 | DYRK1A (0.47) | P2RX3MAPTKMT2A | |
| SCHEMBL7409652 | 0.66 | DYRK1A (0.54) | P2RX3MAPT | |
| SCHEMBL22750785 | 0.66 | NPBWR1 (0.42) | NPBWR1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4204413-A1 | DIHYDROQUINAZOLIN-2-ONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS USEFUL IN THE TREATMENT OF HIV | Merck Sharp & Dohme LLC (US) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022125412-A1 | TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2022046844-A1 | DIHYDROQUINAZOLIN-2-ONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS USEFUL IN THE TREATMENT OF HIV | MERCK SHARP & DOHME CORP. (US) | 2022-03-03 | — | — | WO | disclosed |