Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 7/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907275 | 1.00 | TAS1R3 (0.47) | TAS1R3TAS1R1MAPK1RPS6KA1PDE2A | |
| SCHEMBL2750327 | 0.86 | NR1H4 (0.52) | MAPK1PDE2APPARGCYP17A1CYP3A4 | |
| SCHEMBL2748995 | 0.86 | NR1H4 (0.52) | MAPK1PDE2APPARGCYP17A1CYP3A4 | |
| SCHEMBL1841184 | 0.78 | BRPF1 (0.46) | TAS1R3TAS1R1MAPK1RPS6KA1PDE2A | |
| SCHEMBL2909521 | 0.76 | LMNA (0.55) | MEN1KMT2ANR1H4 | |
| SCHEMBL4547701 | 0.74 | NR1H4 (0.49) | MAPK1PDE2APPARGCYP17A1CYP3A4 | |
| SCHEMBL2912322 | 0.74 | ESRRG (0.56) | — | |
| SCHEMBL2750176 | 0.73 | ROCK2 (0.52) | MAPK1PDE2APPARGCYP17A1CYP3A4 | |
| SCHEMBL4547700 | 0.72 | NR1H4 (0.46) | TAS1R3TAS1R1MAPK1PDE2APPARG | |
| SCHEMBL21467201 | 0.72 | CYP17A1 (0.57) | CYP17A1CYP3A4MEN1KMT2ANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069302-B1 | SUBSTITUTED PYRIDYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2010-08-25 | — | — | EP | disclosed |