SCHEMBL29079982

SCHEMBL29079982

C=C(c1ccc(F)cc1)C1CN1c1ccc(C)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.39
ALDH1A1 P00352 3/20 0.39
UBE2N P61088 1/20 0.39
HSD11B1 P28845 1/20 0.39
HRH3 Q9Y5N1 1/20 0.37
LMNA P02545 2/20 0.36
KMT2A Q03164 3/20 0.35
GAA P10253 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
PAX8 Q06710 1/20 0.35
NPC1 O15118 1/20 0.34
TP53 P04637 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
MAPK1 P28482 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29822795 0.92 MAPT (0.37) ALDH1A1LMNAKMT2AGAAL3MBTL1
SCHEMBL29080004 0.85 ALDH1A1 (0.39) ACHEALDH1A1HRH3LMNAKMT2A
SCHEMBL29079994 0.85 LMNA (0.43) ALDH1A1LMNAKMT2AL3MBTL1NPC1
SCHEMBL29079983 0.84 NPC1 (0.39) ALDH1A1HSD11B1HRH3LMNAKMT2A
SCHEMBL29080008 0.82 LMNA (0.44) ACHEALDH1A1HRH3LMNAKMT2A
SCHEMBL29822631 0.81 GRIK2 (0.36) ALDH1A1LMNAKMT2AL3MBTL1NPC1
SCHEMBL29079995 0.81 GRIK2 (0.36) ALDH1A1LMNAKMT2AL3MBTL1NPC1
SCHEMBL29079997 0.73 LMNA (0.40) LMNAKMT2AL3MBTL1SMN1; SMN2MAPT
SCHEMBL29079988 0.71 ALDH1A1 (0.41) ALDH1A1KMT2ANPC1TP53RAB9A
SCHEMBL13811433 0.68 ACHE (0.62) ACHEALDH1A1LMNAKMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114853664-B Method for synthesizing alpha, beta-unsaturated cyclohexyl ketone compound under palladium catalysis condition 河南大学 2023-09-29 CN disclosed
CN-114853664-A Method for synthesizing alpha, beta-unsaturated heterocyclic hexyl ketone compound under palladium catalysis condition 河南大学 2022-08-05 CN disclosed