SCHEMBL29080002

SCHEMBL29080002

Cc1ccc(C2=CC(=O)N(S(=O)(=O)c3ccc(C)cc3)CC2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.53
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
PKM P14618 3/20 0.50
LMNA P02545 1/20 0.50
THRB P10828 1/20 0.50
HSD11B1 P28845 2/20 0.47
MAPT P10636 1/20 0.47
RECQL P46063 1/20 0.47
ALDH1A1 P00352 1/20 0.45
POLB P06746 1/20 0.45
HTT P42858 1/20 0.45
HTR6 P50406 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
GAA P10253 1/20 0.42
ACHE P22303 1/20 0.42
TSHR P16473 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29079971 0.93 MMP2 (0.47) MMP2CA1CA2PKMLMNA
SCHEMBL29079975 0.93 MMP2 (0.47) MMP2CA1CA2PKMLMNA
SCHEMBL29822774 0.93 LMNA (0.61) MMP2CA1CA2PKMLMNA
SCHEMBL29080011 0.93 HSD11B1 (0.56) MMP2CA1CA2PKMLMNA
SCHEMBL29079987 0.91 MMP2 (0.51) MMP2PKMLMNAHSD11B1MAPT
SCHEMBL29079985 0.91 MMP2 (0.44) MMP2CA1CA2PKMLMNA
SCHEMBL29822623 0.91 MMP2 (0.44) MMP2CA1CA2PKMLMNA
SCHEMBL29079986 0.84 MMP2 (0.46) MMP2CA1CA2PKMLMNA
SCHEMBL29079998 0.82 NPC1 (0.48) MMP2CA1CA2THRBHSD11B1
SCHEMBL14719759 0.77 MMP2 (0.68) MMP2CA1CA2PKMLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114853664-B Method for synthesizing alpha, beta-unsaturated cyclohexyl ketone compound under palladium catalysis condition 河南大学 2023-09-29 CN disclosed
CN-114853664-A Method for synthesizing alpha, beta-unsaturated heterocyclic hexyl ketone compound under palladium catalysis condition 河南大学 2022-08-05 CN disclosed