SCHEMBL29080924

SCHEMBL29080924

OC(F)C(F)(F)c1ccc(Br)nc1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FDFT1 P37268 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL67213 0.76 KMT2A (0.47) KMT2A
SCHEMBL28996832 0.74 CA1 (0.41)
SCHEMBL25100553 0.73 FDFT1 (0.36) FDFT1KMT2A
SCHEMBL30831236 0.73 NR1H2 (0.34) FDFT1KMT2A
SCHEMBL15202873 0.73 NR1H2 (0.47)
SCHEMBL1554553 0.72 MBOAT4 (0.33) KMT2A
SCHEMBL28017609 0.72 L3MBTL1 (0.33) FDFT1KMT2A
SCHEMBL19851267 0.72 KMT2A (0.30) KMT2A
SCHEMBL21437044 0.72 KMT2A (0.33) FDFT1KMT2A
SCHEMBL29153840 0.71 NFKB1 (0.36) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111269221-B Bicyclic lactams and methods of use thereof 豪夫迈·罗氏有限公司 2023-09-26 CN disclosed