Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.51 |
| ▸ | F3 | P13726 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1559466 | 0.87 | HTR3E (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL214780 | 0.85 | ALDH1A1 (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6773778 | 0.85 | PBRM1 (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1081795 | 0.85 | F7 (0.66) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2434449 | 0.81 | NR4A2 (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL31048762 | 0.81 | NR4A2 (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6419348 | 0.81 | F7 (0.51) | F7F3ALDH1A1HPGDCYP1A2 | |
| SCHEMBL2818109 | 0.79 | KDM4E (0.66) | F7F3ALDH1A1HPGDCYP1A2 | |
| SCHEMBL14631139 | 0.79 | F7 (0.50) | F7F3ALDH1A1HPGDCYP1A2 | |
| SCHEMBL30914308 | 0.79 | CYP2A6 (0.54) | F7F3ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1428514-B1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, a tertiary paraphenylenediamine and a benzomorpholine coupler; method and use | OREAL (FR) | 2007-09-19 | — | — | EP | claimed |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | L'OREAL (FR) | 2004-10-21 | — | — | US | claimed |
| EP-0446132-B1 | Keratinous fibres dyeing process with 6 or 7-monohydroxyindols at acidic pH and compositions | OREAL (FR) | 1994-09-14 | — | — | EP | claimed |
| US-5279620-A | Containg paraphenylenediamine, para-aminophenol and paraheterocyclic precursors | L'OREAL (FR) | 1994-01-18 | — | — | US | claimed |
| EP-0446132-A1 | Keratinous fibres dyeing process with 6 or 7-monohydroxyindols at acidic pH and compositions | L'OREAL (FR) | 1991-09-11 | — | — | EP | claimed |
| US-5034015-A | Fade resistant hair dyes with better coloring ability | L'OREAL (FR) | 1991-07-23 | — | — | US | claimed |
| EP-0360638-A1 | Process for dyeing keratinous fibres with an indole derivative associated with a nitrite, and composition therefor | L'OREAL (FR) | 1990-03-28 | — | — | EP | claimed |
| US-20170166561-A1 | QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | ALPHARMAGEN LLC (US) | 2017-06-15 | — | — | US | disclosed |
| EP-2757093-B1 | GUANIDINOBENZOIC ACID COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-12-07 | — | — | EP | disclosed |
| US-9434724-B2 | Quinuclidines for modulating alpha 7 activity | ALPHARMAGEN, LLC (US) | 2016-09-06 | — | — | US | disclosed |
| CN-103796992-B | Guanidinobenzoic acid compound | ASTELLAS PHARMA INC. (JP) | 2016-04-27 | — | — | CN | disclosed |
| US-20160009706-A1 | QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY | ALPHARMAGEN, LLC | 2016-01-14 | — | — | US | disclosed |
| WO-2016007630-A1 | QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7 -NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | ALPHARMAGEN, LLC (US) | 2016-01-14 | — | — | WO | disclosed |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | L'OREAL (FR) | 2004-10-21 | — | — | US | disclosed |
| EP-0446132-B1 | Keratinous fibres dyeing process with 6 or 7-monohydroxyindols at acidic pH and compositions | OREAL (FR) | 1994-09-14 | — | — | EP | disclosed |
| US-5279620-A | Containg paraphenylenediamine, para-aminophenol and paraheterocyclic precursors | L'OREAL (FR) | 1994-01-18 | — | — | US | disclosed |
| US-5207798-A | Hair dyes | L'OREAL (FR) | 1993-05-04 | — | — | US | disclosed |
| EP-0446132-A1 | Keratinous fibres dyeing process with 6 or 7-monohydroxyindols at acidic pH and compositions | L'OREAL (FR) | 1991-09-11 | — | — | EP | disclosed |
| US-5034015-A | Fade resistant hair dyes with better coloring ability | L'OREAL (FR) | 1991-07-23 | — | — | US | disclosed |
| EP-0360638-A1 | Process for dyeing keratinous fibres with an indole derivative associated with a nitrite, and composition therefor | L'OREAL (FR) | 1990-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | CDC73, KRT18, PAH | HTR3E 1579/4885HTR3B 997/4885HTR3A 1360/4885 |
| US-20160009706-A1 | QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY | CHRNA7, CHRNA2, CHRNA5 | HTR3E 346/4885HTR3B 122/4885HTR3A 164/4885 |
| US-20170166561-A1 | QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | CHRNA7, CHRNA2, CHRNA6 | HTR3E 277/4885HTR3B 120/4885HTR3A 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.