Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906226 | 0.81 | CCNT1 (0.41) | SYKGRM4CYP3A4CYP2C19 | |
| SCHEMBL5655346 | 0.69 | IRAK4 (0.36) | KDM4EMEN1TSHRKMT2ATDP1 | |
| SCHEMBL2910038 | 0.68 | SYK (0.39) | SYKGRM4NTRK1 | |
| SCHEMBL2909504 | 0.68 | SYK (0.41) | SYKKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL4136062 | 0.68 | PDE4D (0.37) | SYKLRRK2KDM4EMEN1KMT2A | |
| SCHEMBL2908807 | 0.68 | PDE4D (0.37) | SYKLRRK2KDM4EMEN1KMT2A | |
| SCHEMBL2901842 | 0.66 | PDE4D (0.38) | SYKCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2905403 | 0.64 | PDE4D (0.44) | LRRK2 | |
| SCHEMBL2903176 | 0.64 | PDE4D (0.44) | LRRK2 | |
| SCHEMBL5820437 | 0.63 | MAP4K4 (0.41) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692109-B1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARM CORP (US) | 2010-08-18 | — | — | EP | claimed |