Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.41 |
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902816 | 0.86 | PDCD1 (0.41) | SYKMTORPDCD1CD274 | |
| SCHEMBL2909862 | 0.84 | GSK3B (0.38) | SYKMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL2910850 | 0.84 | MAPT (0.39) | SYKGAAALDH1A1 | |
| SCHEMBL2910038 | 0.77 | SYK (0.39) | SYK | |
| SCHEMBL2901839 | 0.69 | VCP (0.43) | KDM4EALDH1A1 | |
| SCHEMBL2901841 | 0.69 | VCP (0.43) | KDM4EALDH1A1 | |
| SCHEMBL2906226 | 0.69 | CCNT1 (0.41) | SYK | |
| SCHEMBL29672021 | 0.68 | KDM1A (0.53) | PDCD1CD274PDE1B | |
| SCHEMBL2909451 | 0.68 | SYK (0.38) | SYKMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL2903176 | 0.66 | PDE4D (0.44) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692109-B1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARM CORP (US) | 2010-08-18 | — | — | EP | claimed |