Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909504 | 0.77 | SYK (0.41) | SYK | |
| SCHEMBL2908116 | 0.73 | AURKA (0.36) | SYKGRM4XDHAURKAACLY | |
| SCHEMBL2902373 | 0.73 | AURKA (0.36) | SYKGRM4XDHAURKAACLY | |
| SCHEMBL2908119 | 0.72 | XDH (0.36) | SYKXDHAURKA | |
| SCHEMBL2902816 | 0.70 | PDCD1 (0.41) | SYK | |
| SCHEMBL2909862 | 0.70 | GSK3B (0.38) | SYK | |
| SCHEMBL2909451 | 0.68 | SYK (0.38) | SYKGRM4NTRK1 | |
| SCHEMBL2910850 | 0.68 | MAPT (0.39) | SYK | |
| SCHEMBL2906226 | 0.66 | CCNT1 (0.41) | SYKGRM4 | |
| SCHEMBL14032823 | 0.65 | ALDH1A1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692109-B1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARM CORP (US) | 2010-08-18 | — | — | EP | claimed |