Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.34 |
| ▸ | PDE4A | P27815 | 6/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906226 | 0.70 | CCNT1 (0.41) | — | |
| SCHEMBL2909451 | 0.69 | SYK (0.38) | MEN1TSHRKMT2AKDM4ETDP1 | |
| SCHEMBL6174046 | 0.66 | KDM4E (0.56) | MEN1ALDH1A1TSHRKMT2AKDM4E | |
| SCHEMBL2901841 | 0.66 | VCP (0.43) | ALDH1A1KDM4E | |
| SCHEMBL2901839 | 0.66 | VCP (0.43) | ALDH1A1KDM4E | |
| SCHEMBL2905403 | 0.65 | PDE4D (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2903176 | 0.65 | PDE4D (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2901989 | 0.64 | PDE4D (0.42) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5820437 | 0.64 | MAP4K4 (0.41) | TSHRPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2909504 | 0.63 | SYK (0.41) | MEN1ALDH1A1KMT2APDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070049611-A1 | Phosphodiesterase 4 inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049611-A1 | Phosphodiesterase 4 inhibitors | PDE4A, PDE3B, PDE4B | IRAK4 1110/4885MEN1 2795/4885ALDH1A1 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.