Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.35 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.35 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3500515 | 0.68 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10MAPK1MEN1 | |
| SCHEMBL34472003 | 0.67 | MAPT (0.60) | GAAKDM4EHSD17B10HPGDTXNRD1 | |
| SCHEMBL34471357 | 0.67 | GAA (0.70) | GAAPKMKDM4EALDH1A1HSD17B10 | |
| SCHEMBL34472056 | 0.66 | MAPT (0.60) | GAAPKMKDM4EALDH1A1HSD17B10 | |
| SCHEMBL432155 | 0.65 | MAPT (0.57) | PKMKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL12136883 | 0.65 | MAPT (0.33) | GAAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL20428806 | 0.64 | MAPT (0.40) | KDM4EALDH1A1HSD17B10NPSR1MAPK1 | |
| SCHEMBL30965279 | 0.63 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10HPGDCASP1 | |
| SCHEMBL3500609 | 0.62 | CCKBR (0.38) | GAAPKMKDM4EALDH1A1MAPK1 | |
| SCHEMBL3498758 | 0.62 | ALDH1A1 (0.39) | PKMKDM4EALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114195775-B | Fluorescent dye, preparation method thereof and application thereof in bacterial staining | 黄埔海关技术中心 | 2023-11-03 | — | — | CN | disclosed |