Sugi Predict

Sugi Predict / Compounds / SCHEMBL291004

SCHEMBL291004

SCHEMBL291004

Cc1nncc2ccccc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 0.52
▸ KDM4E B2RXH2 4/20 0.52
▸ NPC1 O15118 4/20 0.52
▸ RAB9A P51151 4/20 0.52
▸ SMN1; SMN2 Q16637 3/20 0.52
▸ ALDH1A1 P00352 3/20 0.52
▸ TP53 P04637 2/20 0.52
▸ CYP3A4 P08684 2/20 0.52
▸ GOT1 P17174 2/20 0.52
▸ CYP1A2 P05177 2/20 0.52
▸ CYP2D6 P10635 2/20 0.52
▸ MPO P05164 2/20 0.52
▸ PKM P14618 1/20 0.52
▸ MAOA P21397 1/20 0.52
▸ PTGS1 P23219 1/20 0.52
▸ THPO P40225 1/20 0.52
▸ AOX1 Q06278 1/20 0.52
▸ ACOX1 Q15067 1/20 0.52
▸ MAPT P10636 3/20 0.50
▸ TDP1 Q9NUW8 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24183836 0.79 HPRT1 (0.48) LMNAKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL31678650 0.78 CYP2A6 (0.45) LMNAKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL14478710 0.78 CYP2A6 (0.45) LMNAKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL30523852 0.76 KDM4E (0.55) LMNAKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL1673296 0.76 KDM4E (0.55) LMNAKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL17295055 0.74 NPC1 (0.53) LMNAKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL19153319 0.74 MAOA (0.37) LMNAKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL8404453 0.74 C1S (0.43) LMNAKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL31322056 0.74 KDM4E (0.38) LMNAKDM4ESMN1; SMN2ALDH1A1CYP3A4
SCHEMBL10084142 0.74 KDM4E (0.38) LMNAKDM4ESMN1; SMN2ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 423 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5240924-A Dipeptide hypotensives BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-08-31 — — US claimed
EP-0201221-B1 6-(1-ACYL-1-HYDROXY METHYL) PENICILLANIC ACID DERIVATIVES PFIZER INC. (US) 1990-08-01 — — EP claimed
US-4925901-A STORAGE STAABILITY, ONIUM ION CATALYST THE DOW CHEMICAL COMPANY (US) 1990-05-15 — — US claimed
US-4762921-A 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives PFIZER INC. (US) 1988-08-09 — — US claimed
US-4675186-A 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives PFIZER INC. (US) 1987-06-23 — — US claimed
EP-0201221-A1 6-(1-acyl-1-hydroxy methyl) penicillanic acid derivatives PFIZER INC. (US) 1986-11-12 — — EP claimed
US-20250320184-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF SIRONAX LTD (KY) 2025-10-16 — — US disclosed
US-12421222-B2 Substituted quinazolines as HDAC6 inhibitors AUGUSTINE THERAPEUTICS (BE) 2025-09-23 — — US disclosed
US-20250270220-A1 SOS1 INHIBITORS Mirati Therapeutics, Inc. (US) 2025-08-28 — — US disclosed
US-12304915-B2 SOS1 inhibitors Mirati Therapeutics, Inc. (US) 2025-05-20 — — US disclosed
US-20250145604-A1 COMPOUNDS AND USE THEREOF AS HDAC6 INHIBITORS AUGUSTINE THERAPEUTICS (BE) 2025-05-08 — — US disclosed
US-20250059182-A1 SOS1 INHIBITORS MIRATI THERAPEUTICS, INC 2025-02-20 — — US disclosed
US-20250051319-A1 COMPOUNDS AND USE THEREOF AS HDAC6 INHIBITORS AUGUSTINE THERAPEUTICS (BE) 2025-02-13 — — US disclosed
US-4925901-A STORAGE STAABILITY, ONIUM ION CATALYST THE DOW CHEMICAL COMPANY (US) 1990-05-15 — — US disclosed
US-4871848-A OIL, GAS WELLS CORROSION INHIBITORS THE DOW CHEMICAL COMPANY (US) 1989-10-03 — — US disclosed
EP-0328020-A2 Use of a catalyst in epoxy compositions THE DOW CHEMICAL COMPANY (US) 1989-08-16 — — EP disclosed
US-4762921-A 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives PFIZER INC. (US) 1988-08-09 — — US disclosed
US-4740320-A REACTION OF NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPONENT, KETONE OR ALDEHYDE, AMINE OR POLYAMINE THE DOW CHEMICAL COMPANY (US) 1988-04-26 — — US disclosed
US-4675186-A 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives PFIZER INC. (US) 1987-06-23 — — US disclosed
EP-0201221-A1 6-(1-acyl-1-hydroxy methyl) penicillanic acid derivatives PFIZER INC. (US) 1986-11-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250320184-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF SARM1, SMN1; SMN2, ADRM1 LMNA 907/4885KDM4E 3435/4885NPC1 271/4885
US-20250051319-A1 COMPOUNDS AND USE THEREOF AS HDAC6 INHIBITORS HDAC6, HDAC9, HDAC1 LMNA 2433/4885KDM4E 2750/4885NPC1 620/4885
US-20250145604-A1 COMPOUNDS AND USE THEREOF AS HDAC6 INHIBITORS HDAC6, HDAC9, HDAC1 LMNA 2433/4885KDM4E 2750/4885NPC1 620/4885
US-12304915-B2 SOS1 inhibitors SOS1, SOS2, SAV1 LMNA 3751/4885KDM4E 3245/4885NPC1 759/4885
US-20250059182-A1 SOS1 INHIBITORS SOS1, SOS2, SOST LMNA 3902/4885KDM4E 2892/4885NPC1 517/4885
US-20250270220-A1 SOS1 INHIBITORS SOS1, SOS2, SAV1 LMNA 3751/4885KDM4E 3245/4885NPC1 759/4885
US-12421222-B2 Substituted quinazolines as HDAC6 inhibitors HDAC6, HDAC9, HDAC1 LMNA 2841/4885KDM4E 3008/4885NPC1 916/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.