Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907498 | 0.94 | RAB9A (0.38) | KDM4EPKMKMT2AMEN1LMNA | |
| SCHEMBL2904881 | 0.93 | RAB9A (0.39) | KDM4EPKMKMT2AMEN1LMNA | |
| SCHEMBL2913211 | 0.90 | POLB (0.46) | KDM4EKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL2903975 | 0.90 | POLB (0.39) | KDM4EKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL2904441 | 0.88 | ALDH1A1 (0.35) | KDM4EPKMKMT2AMEN1LMNA | |
| SCHEMBL2908407 | 0.87 | GSK3B (0.34) | MAPTGSK3B | |
| SCHEMBL2910867 | 0.87 | ALDH1A1 (0.33) | KMT2ALMNAALDH1A1POLBHTT | |
| SCHEMBL2909834 | 0.87 | ALDH1A1 (0.33) | KMT2ALMNAALDH1A1POLBHTT | |
| SCHEMBL2910392 | 0.86 | ALDH1A1 (0.35) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL2912942 | 0.86 | ALDH1A1 (0.35) | KMT2AMEN1LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |