Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29119500 | 1.00 | ATAD2 (0.49) | ATAD2NR1H2MAPK1KMT2AGAA | |
| SCHEMBL2061379 | 0.81 | SMN1; SMN2 (0.57) | ATAD2NR1H2MAPK1KMT2AGAA | |
| SCHEMBL1950172 | 0.80 | CASP1 (0.49) | ATAD2CASP1CASP7HSD17B10 | |
| SCHEMBL885867 | 0.79 | DRD1 (0.54) | GAASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL29119426 | 0.79 | DRD2 (0.50) | KMT2AKDM4EALDH1A1MAPTHTR1A | |
| SCHEMBL29119474 | 0.77 | PNMT (0.43) | MAPK1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL2267570 | 0.76 | HTR2A (0.45) | ATAD2KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL618018 | 0.76 | ATAD2 (0.55) | ATAD2KMT2AGAASMN1; SMN2CASP1 | |
| SCHEMBL30168583 | 0.76 | ATAD2 (0.55) | ATAD2KMT2AGAASMN1; SMN2CASP1 | |
| SCHEMBL29119447 | 0.75 | HSP90AA1 (0.48) | KMT2AGAAKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888127-A | Tri-fused ring HPK1 inhibitor and application thereof | 轩竹生物科技股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022188823-A1 | TRICYCLIC HPK1 INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2022-09-15 | — | — | WO | disclosed |