Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Azelaic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD known ✓ | Q03181 | 7/20 | 0.63 |
| ▸ | HDAC11 known ✓ | Q96DB2 | 5/20 | 0.63 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.63 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.63 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.63 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.63 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.63 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.63 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 5/20 | 0.86 |
| ▸ | LMNA | P02545 | 3/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.86 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.86 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.67 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.67 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.67 |
| ▸ | PPARG | P37231 | 7/20 | 0.63 |
| ▸ | PPARA | Q07869 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL28763256 | 1.00 | TSHR (0.86) | TSHRLMNANFKB1PMP22GPR84 | |
| Sebacic Acid SCHEMBL28763255 | 1.00 | TSHR (0.86) | TSHRLMNANFKB1PMP22GPR84 | |
| Sebacic Acid SCHEMBL3832481 | 0.96 | TSHR (0.92) | TSHRLMNANFKB1PMP22GPR84 | |
| Octanedioate SCHEMBL1067156 | 0.96 | TSHR (0.92) | TSHRLMNANFKB1PMP22GPR84 | |
| Ammonia Solution, Strong SCHEMBL14917143 | 0.96 | TSHR (0.92) | TSHRLMNANFKB1PMP22GPR84 | |
| Ammonia Solution, Strong SCHEMBL23212375 | 0.96 | TSHR (0.92) | TSHRLMNANFKB1PMP22GPR84 | |
| Ammonia Solution, Strong SCHEMBL2593810 | 0.96 | TSHR (0.92) | TSHRLMNANFKB1PMP22GPR84 | |
| Sebacic Acid SCHEMBL10820771 | 0.96 | TSHR (0.92) | TSHRLMNANFKB1PMP22GPR84 | |
| Azelaic Acid SCHEMBL1793170 | 0.96 | TSHR (0.92) | TSHRLMNANFKB1PMP22GPR84 | |
| Pimelic Acid SCHEMBL17061400 | 0.96 | TSHR (0.92) | TSHRLMNANFKB1PMP22GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112979451-B | Preparation method of ammonium azelate hydrogen | 南通新宙邦电子材料有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-112979450-B | Preparation method of ammonium azelate hydrogen | 南通新宙邦电子材料有限公司 | 2023-11-03 | — | — | CN | claimed |
| CN-112979451-B | Preparation method of ammonium azelate hydrogen | 南通新宙邦电子材料有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-112979450-B | Preparation method of ammonium azelate hydrogen | 南通新宙邦电子材料有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-112979450-B | Preparation method of ammonium azelate hydrogen | 南通新宙邦电子材料有限公司 | 2023-11-03 | — | — | CN | disclosed |