SCHEMBL29128359

SCHEMBL29128359

S=c1[nH]cc(CSCCCOc2ccccc2)[nH]1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
KDM4E B2RXH2 2/20 0.41
KCNA3 P22001 1/20 0.41
HRH3 Q9Y5N1 1/20 0.38
LMNA P02545 2/20 0.36
MMP2 P08253 1/20 0.36
MMP9 P14780 1/20 0.36
MMP12 P39900 1/20 0.36
AR P10275 2/20 0.35
GAA P10253 1/20 0.35
GFER P55789 1/20 0.35
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29128303 0.93 ALDH1A1 (0.50) ALDH1A1KDM4EKCNA3HRH3LMNA
SCHEMBL29128318 0.86 DRD2 (0.34) ALDH1A1KDM4EHRH3LMNADRD2
SCHEMBL29128423 0.85 RAB9A (0.42) ALDH1A1KDM4ELMNAL3MBTL1
SCHEMBL30800046 0.85 RAB9A (0.42) ALDH1A1KDM4ELMNAL3MBTL1
SCHEMBL29128546 0.83 KCNA3 (0.41) ALDH1A1KDM4EKCNA3HRH3MMP2
SCHEMBL29128222 0.83 HRH3 (0.38) ALDH1A1KDM4EHRH3LMNAGAA
SCHEMBL29128300 0.83 LMNA (0.32) LMNADRD2DRD4DRD3
SCHEMBL29128316 0.82 ALDH1A1 (0.41) ALDH1A1KDM4EHRH3LMNADRD2
SCHEMBL29128229 0.80 LTA4H (0.46) ALDH1A1KDM4ELMNAARSMN1; SMN2
SCHEMBL29128326 0.80 ALDH1A1 (0.37) ALDH1A1KDM4ELMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117263862-A Phenol-1, 3-oxazole/dihydroimidazole-2-ketone/thioketone compound and synthesis and application thereof 吉首大学 2023-12-22 CN disclosed