Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | TK2 | O00142 | 4/20 | 0.40 |
| ▸ | LGALS8 | O00214 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1963526 | 0.89 | PDPK1 (0.46) | PDPK1TK2LGALS8TP53TSHR | |
| Ribose (Furanose) SCHEMBL291402 | 0.81 | PDPK1 (0.61) | PDPK1HSD17B10NPC1RAB9AHTT | |
| SCHEMBL10326198 | 0.72 | LGALS8 (0.49) | TK2LGALS8PRKCA | |
| SCHEMBL10326199 | 0.72 | LGALS8 (0.49) | TK2LGALS8PRKCA | |
| SCHEMBL10326200 | 0.72 | LGALS8 (0.49) | TK2LGALS8PRKCA | |
| SCHEMBL9019466 | 0.71 | SLC29A1 (0.50) | TK2SMN1; SMN2 | |
| SCHEMBL6906126 | 0.71 | PDPK1 (0.51) | PDPK1SMN1; SMN2 | |
| SCHEMBL2199753 | 0.69 | TK2 (0.51) | TK2PRKCA | |
| SCHEMBL2199758 | 0.69 | TK2 (0.51) | TK2PRKCA | |
| SCHEMBL2200265 | 0.69 | TK2 (0.51) | TK2PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308885-B1 | Novel compounds and methods for therapy | GILEAD SCIENCES INC (US) | 2014-11-19 | — | — | EP | claimed |
| EP-2245037-B1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | GILEAD SCIENCES INC (US) | 2014-06-18 | — | — | EP | claimed |
| EP-2308885-A2 | Novel compounds and methods for therapy | Gilead Sciences, Inc. (US) | 2011-04-13 | — | — | EP | claimed |
| US-20090232768-A1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | GILEAD SCIENCES, INC. (US) | 2009-09-17 | — | — | US | claimed |
| EP-4140485-A1 | MODULATORS OF TOLL-LIKE RECEPTORS FOR THE TREATMENT OF HIV | Gilead Sciences, Inc. (US) | 2023-03-01 | — | — | EP | disclosed |
| US-11116774-B2 | Modulators of toll-like receptors for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-11110091-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2021-09-07 | — | — | US | disclosed |
| CN-106714800-B | TOLL-like receptor modulators for the treatment of HIV | 吉利德科学公司 | 2021-09-03 | — | — | CN | disclosed |
| US-20190321366-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2019-10-24 | — | — | US | disclosed |
| US-20190315785-A1 | PHOSPHONATE ANALOGS OF HIV INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2019-10-17 | — | — | US | disclosed |
| EP-3539546-A1 | PHOSPHONATE ANALOGS OF HIV INHIBITOR COMPOUNDS | Gilead Sciences, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| US-10172860-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-5798340-A | ANTITUMOR/ANTINEOPLASTIC ACTIITY, VIRICIDES; BROAD SPECTRUM MICROBIOCIDES; THIOPHOSPHONATES HYDROLYZABLE IN VIVO; ORAL ADMINISTRATION; BIOAVAILABILITY; NONTOXIC; POTENCY | GILEAD SCIENCES, INC. (US) | 1998-08-25 | — | — | US | disclosed |
| US-5767100-A | ADMINISTERING NUCLEOTIDE ANALOGUES TO TREAT HERPES VIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 1998-06-16 | — | — | US | disclosed |
| US-5750729-A | REACTING PROTECTED PYRAN DERIVATIVES TO FORM NUCLEOTIDES | GILEAD SCIENCES,INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5717095-A | PHOSPHONATES CYTOSINE COMPOUND | GILEAD SCIENCES, INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5693771-A | REACTING PROTECTED PYRAN COMPOUND WITH PHOSPHITE AND HETEROCYCLIC BASE | GILEAD SCIENCES, INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5659023-A | HETEROCYCLIC FURANOSYL OR PYRANOSYL PHOSPHONATE; IMMUNOGENS, OLIGONUCLEOTIDES, ANTIINFECTIVES, ANTIINFLAMMATORY AGENTS | GILEAD SCIENCES, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5656745-A | AMIDATE LINKAGE; ANTITUMOR, ANTICARCINOGENIC AGENTS | GILEAD SCIENCES, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| WO-1996033200-A1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AKADEMIE VED C^¿ESKÉ REPUBLIKY (CZ) | 1996-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11116774-B2 | Modulators of toll-like receptors for the treatment of HIV | TLR7, TLR3, TLR6 | PDPK1 1921/4885TK2 745/4885LGALS8 212/4885 |
| US-10172860-B2 | Modulators of toll-like receptors | TLR3, TLR2, TLR6 | PDPK1 2229/4885TK2 1905/4885LGALS8 401/4885 |
| US-11110091-B2 | Modulators of toll-like receptors | TLR3, TLR2, TLR6 | PDPK1 2229/4885TK2 1905/4885LGALS8 401/4885 |
| US-20190315785-A1 | PHOSPHONATE ANALOGS OF HIV INHIBITOR COMPOUNDS | PIK3CA, TYMP, ITPA | PDPK1 112/4885TK2 246/4885LGALS8 3455/4885 |
| US-20190321366-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | PDPK1 2229/4885TK2 1905/4885LGALS8 401/4885 |
| US-20090232768-A1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | TP53, ZC3HAV1, ZFX | PDPK1 3269/4885TK2 82/4885LGALS8 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.