Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | POLQ | O75417 | 6/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472114 | 0.82 | ALDH1A1 (0.49) | RIPK1KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL29184152 | 0.76 | PKM (0.43) | PKMKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL23803539 | 0.73 | RIPK1 (0.43) | RIPK1 | |
| SCHEMBL13830993 | 0.71 | KMT2A (0.42) | PKMKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL307624 | 0.71 | KMT2A (0.42) | PKMKMT2AMEN1POLB | |
| SCHEMBL3313093 | 0.71 | ALDH1A1 (0.43) | KMT2AMEN1ALDH1A1POLQNR1H3 | |
| SCHEMBL29013248 | 0.70 | PKM (0.44) | PKMKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL23819831 | 0.70 | RIPK1 (0.43) | RIPK1 | |
| SCHEMBL307698 | 0.69 | OPRK1 (0.47) | PKMKMT2APOLB | |
| SCHEMBL4746141 | 0.69 | KMT2A (0.51) | KMT2AMEN1ALDH1A1POLBPOLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214487-A1 | NOVEL SEH INHIBITORS AND THEIR USE | GlaxoSmithKline LLC (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009049157-A1 | NOVEL SEH INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |