Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pyrrolidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrolidine SCHEMBL28575035 | 0.91 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2 | |
| Pyrrolidine SCHEMBL29601650 | 0.91 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2 | |
| Pyrrolidine SCHEMBL23354581 | 0.91 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2 | |
| Pyrrolidine SCHEMBL28409763 | 0.88 | ALDH1A1 (0.50) | ALDH1A1CXCR4SMN1; SMN2 | |
| Piperidine SCHEMBL5874242 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CXCR4SMN1; SMN2 | |
| Piperidine SCHEMBL1242732 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CXCR4SMN1; SMN2 | |
| Piperidine SCHEMBL9857707 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CXCR4SMN1; SMN2 | |
| Piperidine SCHEMBL5874248 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CXCR4SMN1; SMN2 | |
| Azepane SCHEMBL7914286 | 0.85 | ALDH1A1 (0.56) | ALDH1A1CXCR4SMN1; SMN2 | |
| Phosphoric Acid SCHEMBL28853896 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118339165-A | Antibody-drug conjugates and methods of use thereof | R.P.谢勒技术有限责任公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-117279662-A | Branched linkers for antibody-drug conjugates and methods of use thereof | R.P.谢勒技术有限责任公司 | 2023-12-22 | — | — | CN | disclosed |