Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | POLB | P06746 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30622193 | 0.88 | TLR8 (0.43) | NOTUMMAPTPOLBKDM4EHSD17B10 | |
| SCHEMBL29133160 | 0.86 | SMN1; SMN2 (0.41) | NOTUMMAPTPOLBKDM4EHSD17B10 | |
| SCHEMBL29133041 | 0.84 | KDM4E (0.52) | NOTUMMAPTPOLBKDM4EHSD17B10 | |
| SCHEMBL29133017 | 0.84 | DGAT1 (0.50) | NOTUMMAPTPOLBKDM4EHSD17B10 | |
| SCHEMBL30622248 | 0.83 | KDM4E (0.49) | NOTUMMAPTPOLBKDM4EHSD17B10 | |
| SCHEMBL29133007 | 0.82 | MAPT (0.48) | MAPTPOLBALDH1A1KMT2ARAB9A | |
| SCHEMBL29133117 | 0.81 | HDAC6 (0.45) | — | |
| SCHEMBL5115763 | 0.80 | MAPT (0.58) | MAPTPOLBKDM4EHSD17B10LMNA | |
| SCHEMBL29133055 | 0.80 | ALDH1A1 (0.52) | MAPTPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL29133097 | 0.77 | ALDH1A1 (0.52) | NOTUMMAPTKDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117088884-A | Imidazopyridazine derivatives as GABAA receptor modulators, pharmaceutical compositions and uses | 上海赛默罗德生物科技有限公司 | 2023-11-21 | — | — | CN | disclosed |