Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22090295 | 0.84 | HCRTR1 (0.41) | HCRTR2HCRTR1ADORA3 | |
| SCHEMBL22262804 | 0.82 | SHMT1 (0.39) | ADRA1AADRA1BHCRTR2HCRTR1HPGDS | |
| SCHEMBL1586163 | 0.81 | SLC6A3 (0.54) | POLBTDP1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL28619053 | 0.80 | ADORA3 (0.44) | ADRA1AADRA1BPOLBHPGDSGABRA1 | |
| SCHEMBL31707778 | 0.80 | HCRTR1 (0.47) | HCRTR2HCRTR1POLBGABRA1GABRG2 | |
| SCHEMBL17448835 | 0.80 | HCRTR2 (0.43) | HCRTR2HCRTR1 | |
| SCHEMBL17584558 | 0.79 | HPGDS (0.39) | ADRA1AADRA1BHCRTR1HPGDSGABRP | |
| SCHEMBL109178 | 0.78 | TSHR (0.50) | ADRA1AADRA1BTDP1ALDH1A1TSHR | |
| SCHEMBL30111657 | 0.78 | TSHR (0.50) | ADRA1AADRA1BTDP1ALDH1A1TSHR | |
| SCHEMBL29389473 | 0.78 | BCAT2 (0.52) | POLBADORA3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |