Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28796630 | 0.76 | HTT (0.45) | ALDH1A1HPGDCYP1A2HTTNPSR1 | |
| SCHEMBL29635285 | 0.74 | HTT (0.42) | ALDH1A1CYP1A2HTTMAPTGAA | |
| SCHEMBL29635286 | 0.71 | HTT (0.41) | ALDH1A1CYP1A2HTTMAPTGAA | |
| SCHEMBL29635284 | 0.71 | CNR2 (0.41) | ALDH1A1HPGDCNR2CNR1HTT | |
| SCHEMBL29140074 | 0.65 | KMT2A (0.48) | ALDH1A1CYP1A2HTTMAPTGAA | |
| SCHEMBL29635290 | 0.65 | MAPT (0.44) | ALDH1A1HPGDKDM4ECYP1A2NPC1 | |
| SCHEMBL10059357 | 0.63 | KDM4E (0.79) | ALDH1A1HPGDKDM4ECYP1A2BLM | |
| Pirfenidone SCHEMBL4708 | 0.62 | KDM4E (1.00) | ALDH1A1HPGDKDM4ECYP1A2BLM | |
| Pirfenidone SCHEMBL1006039 | 0.62 | KDM4E (1.00) | ALDH1A1HPGDKDM4ECYP1A2BLM | |
| SCHEMBL10059350 | 0.61 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4ECYP1A2BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114671868-B | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2023-03-31 | — | — | CN | claimed |
| CN-114671868-A | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2022-06-28 | — | — | CN | claimed |
| CN-114671868-B | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2023-03-31 | — | — | CN | disclosed |
| CN-114671868-A | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2022-06-28 | — | — | CN | disclosed |