SCHEMBL2914543

SCHEMBL2914543

CC(=O)CC(=O)Nc1ccc(NC(=O)CC(C)=O)c(Oc2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.57
ALDH1A1 P00352 4/20 0.57
MEN1 O00255 3/20 0.57
KDM4E B2RXH2 2/20 0.57
CYP1A2 P05177 1/20 0.57
CYP2C19 P33261 1/20 0.57
HIF1A Q16665 1/20 0.57
ADRA2C P18825 1/20 0.55
MAPT P10636 2/20 0.52
POLB P06746 4/20 0.51
LMNA P02545 1/20 0.51
GAA P10253 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
ATM Q13315 1/20 0.50
P2RY1 P47900 1/20 0.50
PDE4B Q07343 1/20 0.48
MITF O75030 1/20 0.47
MAPK1 P28482 1/20 0.47
HTT P42858 1/20 0.47
RNF4 P78317 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2914555 0.81 MEN1 (0.66) KMT2AALDH1A1MEN1KDM4ECYP1A2
SCHEMBL2908421 0.79 KDM4E (0.51) KMT2AALDH1A1MEN1KDM4ECYP1A2
SCHEMBL2906339 0.78 RORC (0.49) KMT2AALDH1A1MEN1KDM4ECYP1A2
SCHEMBL11782499 0.77 L3MBTL1 (0.72) KMT2AALDH1A1MEN1CYP1A2CYP2C19
SCHEMBL2913591 0.77 MAPT (0.55) KMT2AALDH1A1MEN1KDM4ECYP1A2
SCHEMBL28893860 0.76 PDE4B (0.63) KMT2AALDH1A1MEN1KDM4ECYP1A2
SCHEMBL2912941 0.76 POLB (0.52) KMT2AALDH1A1MEN1KDM4ECYP1A2
SCHEMBL10027978 0.75 ADRA2C (0.79) KMT2AALDH1A1MEN1KDM4EADRA2C
SCHEMBL11427058 0.74 MAPT (0.61) KMT2AALDH1A1MEN1KDM4ECYP1A2
SCHEMBL11314859 0.74 L3MBTL1 (0.46) KMT2AALDH1A1MEN1CYP2C19ADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6756486-B1 LAKED DISAZO YELLOW PIGMENTS HAVING DESIRABLE GREEN SHADE, HEAT STABILITY, GOOD STRENGTH, BLEED RESISTANCE, MIGRATION RESISTANCE, AND LOW OR NO TOXICITY ENGELHARD CORPORATION 2004-06-29 US claimed
EP-1668080-B1 NON-MIGRATING MEALLIZED DISAZO GREEN SHADE YELLOW PIGMENT ENGELHARD CORP (US) 2010-08-11 EP disclosed
US-7262284-B2 Method for producing disazo pigments CLARIANT PRODUKTE (DEUTSCHLAND) GMBH (DE) 2007-08-28 US disclosed
US-20060167236-A1 Method for producing disazo pigments CLARIANT GMBH (DE) 2006-07-27 US disclosed
EP-1668080-A1 NON-MIGRATING MEALLIZED DISAZO GREEN SHADE YELLOW PIGMENT Engelhard Corporation (US) 2006-06-14 EP disclosed
WO-2005033212-A1 NON-MIGRATING MEALLIZED DISAZO GREEN SHADE YELLOW PIGMENT ENGELHARD CORPORATION (US) 2005-04-14 WO disclosed
EP-1517962-A1 METHOD FOR PRODUCING DISAZO PIGMENTS Clariant GmbH (DE) 2005-03-30 EP disclosed
US-6756486-B1 LAKED DISAZO YELLOW PIGMENTS HAVING DESIRABLE GREEN SHADE, HEAT STABILITY, GOOD STRENGTH, BLEED RESISTANCE, MIGRATION RESISTANCE, AND LOW OR NO TOXICITY ENGELHARD CORPORATION 2004-06-29 US disclosed
WO-2004000947-A1 METHOD FOR PRODUCING DISAZO PIGMENTS CLARIANT GMBH (DE) 2003-12-31 WO disclosed
EP-1104444-B1 STRONG GREEN-SHADE YELLOW DISAZO PIGMENT ENGELHARD CORP (US) 2002-12-18 EP disclosed
US-6254671-B1 Very green-shade yellow metallized disazo pigment ENGELHARD CORPORATION 2001-07-03 US disclosed
EP-1104444-A1 STRONG GREEN-SHADE YELLOW DISAZO PIGMENT Engelhard Corporation (US) 2001-06-06 EP disclosed
WO-2001036540-A1 VERY GREEN-SHADE YELLOW METALLIZED DISAZO PIGMENT ENGELHARD CORPORATION (US) 2001-05-25 WO disclosed
WO-2000009614-A1 STRONG GREEN-SHADE YELLOW DISAZO PIGMENT ENGELHARD CORPORATION (US) 2000-02-24 WO disclosed
US-5889162-A COUPLING A DIAZONIUM COMPONENT MADE FROM ONE OR MORE AROMATIC AMINES SUCH AS 2-ETHOXYANILINE WITH AT LEAST ONE COUPLING AGENT; SUITABLE FOR USE IN PLASTICS, PAINTS AND INKS ENGELHARD CORPORATION (US) 1999-03-30 US disclosed
EP-0585873-B1 Method of preparing disazo pigments CLARIANT GMBH (DE) 1997-12-29 EP disclosed
US-5559216-A AZO COUPLING HOECHST AG (DE) 1996-09-24 US disclosed
EP-0585873-A1 Method of preparing disazo pigments HOECHST AKTIENGESELLSCHAFT (DE) 1994-03-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060167236-A1 Method for producing disazo pigments TYR, IPO4, CBR3 KMT2A 2138/4885ALDH1A1 560/4885MEN1 2054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.