Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29189923 | 0.84 | LCK (0.43) | MAPTPOLBMAPK1LMNANPC1 | |
| SCHEMBL187734 | 0.81 | ALDH1A1 (0.44) | MAPTPOLBHPGDMAPK1LMNA | |
| SCHEMBL18725355 | 0.78 | SMN1; SMN2 (0.46) | NOTUMMAPTHPGDMAPK1LMNA | |
| SCHEMBL29556542 | 0.78 | MAPT (0.42) | MAPTPOLBHPGDMAPK1LMNA | |
| SCHEMBL20266533 | 0.78 | MAPT (0.42) | MAPTPOLBHPGDMAPK1LMNA | |
| SCHEMBL17144343 | 0.76 | NOTUM (0.46) | NOTUMMAPTMAPK1NPC1TP53 | |
| SCHEMBL30405765 | 0.76 | NOTUM (0.46) | NOTUMMAPTMAPK1NPC1TP53 | |
| SCHEMBL31661385 | 0.75 | NOTUM (0.45) | NOTUMMAPTMAPK1NPC1TP53 | |
| SCHEMBL11832462 | 0.74 | VCAM1 (0.52) | MAPTPOLBHPGDMAPK1LMNA | |
| SCHEMBL5117547 | 0.74 | CNR2 (0.40) | MAPTPOLBHPGDRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117177970-A | Polycyclic derivative regulator, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-12-05 | — | — | CN | disclosed |
| WO-2022228490-A1 | POLYCYCLIC DERIVATIVE MODULATOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2022-11-03 | — | — | WO | disclosed |