Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 2/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29168410 | 0.85 | KRAS (0.36) | KRASSOS1PDE10AKDM4ENPC1 | |
| SCHEMBL29168349 | 0.82 | RXFP1 (0.37) | PDE10ATP53RXFP1IRAK4KDM4E | |
| SCHEMBL29168452 | 0.71 | LMNA (0.35) | KRASSOS1LMNATP53RXFP1 | |
| SCHEMBL29168355 | 0.67 | KRAS (0.35) | KRASSOS1HPGDRAB9A | |
| SCHEMBL27186284 | 0.66 | KRAS (0.47) | KRASSOS1 | |
| SCHEMBL27186280 | 0.66 | KRAS (0.47) | KRASSOS1 | |
| SCHEMBL29168387 | 0.66 | RXFP1 (0.33) | KRASSOS1LMNATP53RXFP1 | |
| SCHEMBL29168384 | 0.66 | RXFP1 (0.33) | KRASSOS1PDE10ATP53RXFP1 | |
| SCHEMBL22827019 | 0.64 | KRAS (0.68) | KRASSOS1 | |
| SCHEMBL29168408 | 0.63 | POLB (0.36) | KRASSOS1TP53KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |