SCHEMBL2917271

SCHEMBL2917271

CC(N)CCN(C)C(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC2 Q92769 1/20 0.39
CTSK P43235 3/20 0.38
CHRNB2 P17787 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA4 P43681 1/20 0.36
GABRP O00591 2/20 0.35
GABRD O14764 2/20 0.35
GABRA1 P14867 2/20 0.35
GABRB1 P18505 2/20 0.35
GABRG2 P18507 2/20 0.35
GABRB3 P28472 2/20 0.35
GABRA5 P31644 2/20 0.35
GABRA3 P34903 2/20 0.35
GABRA2 P47869 2/20 0.35
GABRB2 P47870 2/20 0.35
GABRA4 P48169 2/20 0.35
GABRE P78334 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24753485 0.85 HDAC6 (0.35) HDAC6HDAC1HDAC2CTSKCHRNB2
SCHEMBL16941095 0.85 CTSK (0.39) HDAC6HDAC1HDAC2CTSKCHRNB2
SCHEMBL3711368 0.84 CTSK (0.38) HDAC6HDAC1HDAC2CTSKCHRNB2
SCHEMBL21258550 0.83 CTSK (0.37) CTSKCHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL19709285 0.83 CTSK (0.36) HDAC6HDAC1HDAC2CTSKCHRNB2
SCHEMBL21610069 0.82 CTSK (0.38) HDAC6HDAC1HDAC2CTSKCHRNB2
SCHEMBL25113381 0.82 CTSK (0.38) HDAC6HDAC1HDAC2CTSKCHRNB2
SCHEMBL3708518 0.82 CTSK (0.38) HDAC6HDAC1HDAC2CTSKCHRNB2
SCHEMBL18431705 0.82 CTSK (0.38) HDAC6HDAC1HDAC2CTSKCHRNB2
SCHEMBL14547678 0.82 CTSK (0.38) HDAC6HDAC1HDAC2CTSKCHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12145913-B2 Inhibition of Olig2 activity Curtana Pharmaceuticals, Inc. (US) 2024-11-19 US disclosed
WO-2024020522-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 ARVINAS OPERATIONS, INC. (US) 2024-01-25 WO disclosed
US-20240018150-A1 SMALL MOLECULAR INHIBITOR AGAINST BTK AND/OR BTK C481S AND USE THEREOF ARROMAX PHARMATECH CO., LTD. (CN) 2024-01-18 US disclosed
US-11820775-B2 Pyrrolopyrimidine ITK inhibitors ACLARIS THERAPEUTICS, INC. (US) 2023-11-21 US disclosed
US-20230295149-A1 MONOBACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS NINGXIA ACADEMY OF AGRICULTURE AND FORESTRY SCIENCES (CN) 2023-09-21 US disclosed
US-11731986-B2 Inhibitors of low molecular weight protein tyrosine phosphatase (LMPTP) and uses thereof Sanford Burnham Prebys Medical Discovery Institute (US) 2023-08-22 US disclosed
US-20230149550-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-05-18 US disclosed
US-20230150996-A1 B-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS NINGXIA ACADEMY OF AGRICULTURE AND FORESTRY SCIENCES (CN) 2023-05-18 US disclosed
US-20230029557-A1 INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute 2023-02-02 US disclosed
WO-2022266258-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 ARVINAS OPERATIONS, INC. (US) 2022-12-22 WO disclosed
US-9556165-B2 Amidine substituted β-lactam compounds, their preparation and use as antibacterial agents AICURIS GMBH & CO. KG (DE) 2017-01-31 US disclosed
US-8957082-B2 Tetrahydropyrrolopyrimidinediones and their use in therapy CHIESI FARMACEUTICI S.P.A (IT) 2015-02-17 US disclosed
US-20120202826-A1 Tetrahydropyrrolopyrimidinediones And Their Use In Therapy CHIESI FARMACEUTICI S.P.A. (IT) 2012-08-09 US disclosed
US-8198288-B2 Tetrahydropyrrolopyrimidinediones and their use in therapy PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED (GB) 2012-06-12 US disclosed
EP-2024367-B1 TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS PULMAGEN THERAPEUTICS INFLAMMA (GB) 2010-09-08 EP disclosed
WO-2010009207-A1 BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS GPCR MODULATORS SCHERING CORPORATION (US) 2010-01-21 WO disclosed
US-20090093477-A1 TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE IN THERAPY CHIESI FARMACEUTICI S.P.A. (IT) 2009-04-09 US disclosed
EP-2024367-A1 TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS Argenta Discovery Limited (GB) 2009-02-18 EP disclosed
WO-2007129060-A1 TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS ARGENTA DISCOVERY LIMITED (GB) 2007-11-15 WO disclosed
WO-2007030080-A1 HETEROCYCLIC COMPOUNDS S*BIO PTE LTD (SG) 2007-03-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150996-A1 B-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS LBR, MRPL21, MRPL19 HDAC6 1320/4885HDAC1 1066/4885HDAC2 2650/4885
US-20230029557-A1 INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF ACP1, PTPRCAP, PTPRO HDAC6 1809/4885HDAC1 790/4885HDAC2 2469/4885
US-20230149550-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE DMPK, DTYMK, MYCBP HDAC6 948/4885HDAC1 551/4885HDAC2 1636/4885
US-11731986-B2 Inhibitors of low molecular weight protein tyrosine phosphatase (LMPTP) and uses thereof ACP1, PTPRCAP, PTPRO HDAC6 1809/4885HDAC1 790/4885HDAC2 2469/4885
US-20120202826-A1 Tetrahydropyrrolopyrimidinediones And Their Use In Therapy SERPINB1, ELANE, MPO HDAC6 396/4885HDAC1 457/4885HDAC2 963/4885
US-12145913-B2 Inhibition of Olig2 activity POU2F2, POU2F1, PLP2 HDAC6 632/4885HDAC1 517/4885HDAC2 478/4885
US-20090093477-A1 TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE IN THERAPY NOX1, NOX3, ELANE HDAC6 2195/4885HDAC1 1055/4885HDAC2 2464/4885
US-20230295149-A1 MONOBACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS MRPL21, MRPL19, MRPL12 HDAC6 3872/4885HDAC1 1077/4885HDAC2 3960/4885
US-20240018150-A1 SMALL MOLECULAR INHIBITOR AGAINST BTK AND/OR BTK C481S AND USE THEREOF BTK, SYK, LCK HDAC6 347/4885HDAC1 965/4885HDAC2 756/4885
US-11820775-B2 Pyrrolopyrimidine ITK inhibitors ITK, PDXK, DMPK HDAC6 3025/4885HDAC1 2049/4885HDAC2 2213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.