Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18319815 | 0.96 | OPRL1 (0.32) | OPRL1 | |
| SCHEMBL26920918 | 0.76 | PTPN11 (0.35) | — | |
| SCHEMBL24983176 | 0.74 | OPRL1 (0.33) | OPRL1 | |
| SCHEMBL18328487 | 0.74 | OPRL1 (0.33) | OPRL1 | |
| SCHEMBL28907374 | 0.74 | OPRL1 (0.33) | OPRL1 | |
| SCHEMBL29041433 | 0.74 | OPRL1 (0.34) | OPRL1 | |
| SCHEMBL21287272 | 0.74 | KDM4E (0.38) | OPRL1 | |
| SCHEMBL31184367 | 0.73 | OPRL1 (0.32) | OPRL1 | |
| SCHEMBL28456562 | 0.73 | OPRL1 (0.32) | OPRL1 | |
| SCHEMBL31317500 | 0.70 | OPRL1 (0.32) | OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113493440-B | Salt of nitrogen-containing heteroaromatic derivative and crystal form thereof | 上海翰森生物医药科技有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-115052866-B | Crystal form of nitrogen-containing heteroaromatic derivative free alkali | 上海翰森生物医药科技有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-115353509-B | Nitrogen-containing heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-04-12 | — | — | CN | disclosed |