Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 6/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL3685225 | 0.92 | HCAR2 (0.50) | HCAR2ACHEBACE1PLA2G1BATG4B | |
| Maleic Acid SCHEMBL538717 | 0.92 | HCAR2 (0.50) | HCAR2ACHEBACE1PLA2G1BATG4B | |
| Maleic Acid SCHEMBL1274105 | 0.92 | HCAR2 (0.50) | HCAR2ACHEBACE1PLA2G1BATG4B | |
| Fumaric Acid SCHEMBL48773 | 0.92 | HCAR2 (0.50) | HCAR2ACHEBACE1PLA2G1BATG4B | |
| Maleic Acid SCHEMBL28530087 | 0.90 | HCAR2 (0.48) | HCAR2ACHEBACE1PLA2G1BATG4B | |
| Maleic Acid SCHEMBL3629094 | 0.90 | HCAR2 (0.48) | HCAR2ACHEBACE1PLA2G1BATG4B | |
| Maleic Acid SCHEMBL28981641 | 0.86 | HCAR2 (0.46) | HCAR2ACHEBACE1PLA2G1BATG4B | |
| Maleic Acid SCHEMBL28649558 | 0.86 | HCAR2 (0.52) | HCAR2PLA2G1BATG4BTHRATHRB | |
| Fumaric Acid SCHEMBL901027 | 0.83 | HCAR2 (0.53) | HCAR2PLA2G1BATG4BTHRATHRB | |
| Maleic Acid SCHEMBL900756 | 0.83 | HCAR2 (0.53) | HCAR2PLA2G1BATG4BTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220174-A1 | COATING AGENT WITH DOUBLE CROSS-LINKING | Henkel AG & Co. KGaA (DE) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009074365-A1 | COATING AGENT WITH DOUBLE CROSS-LINKING | HENKEL AG & CO. KGAA (DE) | 2009-06-18 | — | — | WO | disclosed |