Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 6/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 6/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL3685225 | 1.00 | HCAR2 (0.50) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL538717 | 1.00 | HCAR2 (0.50) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL1274105 | 1.00 | HCAR2 (0.50) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL28530087 | 0.98 | HCAR2 (0.48) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL3629094 | 0.98 | HCAR2 (0.48) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL28981641 | 0.94 | HCAR2 (0.46) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL28649558 | 0.94 | HCAR2 (0.52) | HCAR2PLA2G1BATG4BTHRATHRB | |
| Maleic Acid SCHEMBL2919006 | 0.92 | HCAR2 (0.44) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL901027 | 0.91 | HCAR2 (0.53) | HCAR2PLA2G1BATG4BTHRATHRB | |
| Fumaric Acid SCHEMBL384277 | 0.91 | HCAR2 (0.53) | HCAR2PLA2G1BATG4BTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 11656 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956368-B1 | LATENT CATALYST | DOW GLOBAL TECHNOLOGIES LLC (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122060237-A | Silane self-crosslinking polyethylene pipe with antibacterial property and preparation method thereof | 日丰企业（佛山）有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-119592294-B | Quick-curing bi-component condensation dealcoholized silicone adhesive and preparation method thereof | 万华化学集团股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122037135-A | Composition, polyurethane foam material, preparation method of polyurethane foam material and refrigeration equipment | TCL家用电器（合肥）有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122037116-A | Combined polyether, polyurethane composition, polyurethane foam, preparation method of polyurethane foam and refrigeration equipment | TCL家用电器（合肥）有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4530311-B1 | MICROCELLULAR FOAMED AND THERMALLY INSULATED DOOR SEALING MATERIAL AND PREPARATION METHOD THEREOF | QINGDAO JIESHENG NEW MATERIAL TECH CO LTD (CN) | 2026-04-08 | — | — | EP | claimed |
| CN-121574564-A | Liquid silicone rubber for cold-shrink cable accessories and preparation method thereof | 东莞市正安有机硅科技有限公司 | 2026-02-27 | — | — | CN | claimed |
| CN-121572687-A | Layered flame-retardant polyurethane composite material and preparation method thereof | 深圳市力信陆南实业有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-20260015521-A1 | THERMOSETTING COATING COMPOSITION WITH IMPROVED SCRATCH RESISTANCE | EASTMAN CHEMICAL COMPANY (US) | 2026-01-15 | — | — | US | claimed |
| EP-4663686-A1 | ELECTRICALLY DEBONDABLE SILYL MODIFIED POLYMER-BASED ADHESIVE | Henkel AG & Co. KGaA (DE) | 2025-12-17 | — | — | EP | claimed |
| US-4151132-A | VIDEO DISCS | RCA CORPORATION (US) | 1979-04-24 | — | — | US | claimed |
| US-4147636-A | FOR POLYPROPYLENE | SANDOZ LTD. (CH) | 1979-04-03 | — | — | US | claimed |
| EP-0000792-A1 | X-ray image intensifying screens | AGFA-GEVAERT N.V. (BE) | 1979-02-21 | — | — | EP | claimed |
| US-4138361-A | IMAGE INTENSIFIER; HALIDE-CONTAINING PHOSPHOR, ORGANO-METALLIC SUBSTANCE AS STABILIZER | AGFA-GEVAERT N.V. (BE) | 1979-02-06 | — | — | US | claimed |
| US-4137211-A | FIREPROOFING | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1979-01-30 | — | — | US | claimed |
| US-4089912-A | DIALKYLTIN MALEATE, PHENOLIC ANTIOXIDANT; ESTERS, IMIDES, OR ANHYDRIDES OF CYCLIC DICARBOXYLIC ACIDS, OR POLYMERIC ESTERS | GREAT LAKES CHEMICAL CORPORATION (US) | 1978-05-16 | — | — | US | claimed |
| US-4061844-A | AMINOALKYL ACRYLATE COPOLYMER, SILICON OR TIN COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-12-06 | — | — | US | claimed |
| US-4052350-A | CALCIUM COMPOUND | SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA (JA) | 1977-10-04 | — | — | US | claimed |
| US-4002809-A | Method of manufacturing acrylic fibers | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JA) | 1977-01-11 | — | — | US | claimed |
| US-3962155-A | MOLDED FOAMS AND PROCESS FOR PRODUCING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-06-08 | — | — | US | claimed |