Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | HRAS | P01112 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2944297 | 0.85 | PIM1 (0.48) | PIM1PIM3POLBCHRM2CHRM1 | |
| SCHEMBL2924665 | 0.82 | PIM1 (0.46) | PIM1PIM3POLBPIN1CHRM2 | |
| SCHEMBL2920081 | 0.81 | PIM1 (0.52) | PIM1PIM3POLBHRASALDH1A1 | |
| SCHEMBL4155798 | 0.80 | KMT2A (0.52) | PIM1PIM3POLBCHRM2CHRM1 | |
| SCHEMBL10648737 | 0.80 | PIM3 (0.55) | PIM1PIM3POLBPIN1HRAS | |
| SCHEMBL7714632 | 0.79 | PIM1 (0.45) | PIM1PIM3POLBCHRM2CHRM1 | |
| SCHEMBL2921828 | 0.78 | ADORA2A (0.59) | PIM1PIM3POLBCHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL2923105 | 0.77 | ADORA2A (0.58) | PIM1PIM3POLBCHRM2CHRM1 | |
| SCHEMBL2914278 | 0.77 | ADORA2A (0.61) | PIM1PIM3POLBCHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL2922562 | 0.77 | ADORA2A (0.60) | PIM1PIM3POLBCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261325-B1 | TUMOR INHIBITING COMPOSITIONS COMPRISING NITROACRIDINES | NEW YORK MEDICAL COLLEGE (US) | 2010-09-08 | — | — | EP | disclosed |
| US-7622478-B2 | 1-nitroacridine/tumor inhibitor compositions | TIWARI RAJ | 2009-11-24 | — | — | US | disclosed |
| US-6589961-B2 | For inhibiting metastases of a tumor in a mammal | NEW YORK MEDICAL COLLEGE | 2003-07-08 | — | — | US | disclosed |
| US-20020099211-A1 | 9-alkylamino-1-nitroacridine derivatives | NEW YORK MEDICAL COLLEGE | 2002-07-25 | — | — | US | disclosed |
| US-20020037831-A1 | 1-Nitroacridine/tumor inhibitor compositions | TIWARI RAJ (US) | 2002-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099211-A1 | 9-alkylamino-1-nitroacridine derivatives | NPPA, ABCB11, ABCC9 | PIM1 3803/4885PIM3 3397/4885POLB 2534/4885 |
| US-20020037831-A1 | 1-Nitroacridine/tumor inhibitor compositions | MKI67, DIAPH1, API5 | PIM1 890/4885PIM3 2269/4885POLB 1867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.