Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15322852 | 0.79 | NOS1 (0.54) | MAPTMAPK1ALDH1A1NPSR1GAA | |
| SCHEMBL15322849 | 0.79 | NOS1 (0.54) | MAPTMAPK1ALDH1A1NPSR1GAA | |
| SCHEMBL15323693 | 0.77 | MAPT (0.57) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL15323697 | 0.77 | MAPT (0.57) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL29201789 | 0.76 | ALDH1A1 (0.51) | KDM4EMAPTMAPK1ALDH1A1TDP1 | |
| SCHEMBL2862977 | 0.75 | KDM4E (0.53) | KDM4EMAPTMAPK1ALDH1A1TDP1 | |
| SCHEMBL13025195 | 0.75 | KDM4E (0.53) | KDM4EMAPTMAPK1ALDH1A1TDP1 | |
| SCHEMBL2862976 | 0.75 | KDM4E (0.53) | KDM4EMAPTMAPK1ALDH1A1TDP1 | |
| SCHEMBL2309322 | 0.74 | KMT2A (0.73) | KDM4EMAPTMAPK1ALDH1A1TDP1 | |
| SCHEMBL2867063 | 0.71 | CES2 (0.59) | KDM4EMAPTMAPK1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924177-A | Preparation method of pazopanib intermediate 2, 3-dimethyl-6-amino-2H-indazole and analogues thereof | 南京杰运医药科技有限公司 | 2024-04-26 | — | — | CN | disclosed |