Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059503 | 0.77 | KMT2A (0.47) | LMNASMN1; SMN2RAB9AMAPTGAA | |
| SCHEMBL29202241 | 0.72 | DRD4 (0.42) | LMNASMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL10703573 | 0.71 | RAB9A (0.57) | LMNASMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL29202242 | 0.70 | LMNA (0.38) | LMNASMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL4624964 | 0.69 | — | — | |
| SCHEMBL29202189 | 0.69 | LMNA (0.38) | LMNASMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL27238536 | 0.69 | PARP1 (0.33) | KMT2A | |
| SCHEMBL1429528 | 0.67 | MAPT (0.47) | LMNASMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL11253494 | 0.67 | LMNA (0.56) | LMNASMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL7820863 | 0.67 | ALDH1A1 (0.68) | LMNASMN1; SMN2RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964639-A | Pyridazine compound containing benzo heterocyclic structure, pharmaceutical composition and application thereof | 中国药科大学 | 2024-05-03 | — | — | CN | disclosed |