Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | HCK | P08631 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29202241 | 0.83 | DRD4 (0.42) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL29202189 | 0.77 | LMNA (0.38) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL29202211 | 0.70 | LMNA (0.43) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4624964 | 0.68 | — | — | |
| SCHEMBL29202265 | 0.67 | MEN1 (0.45) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL10703573 | 0.66 | RAB9A (0.57) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1429528 | 0.62 | MAPT (0.47) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11253494 | 0.62 | LMNA (0.56) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL29190597 | 0.62 | KDM4E (0.61) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL7820863 | 0.62 | ALDH1A1 (0.68) | LMNASMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964639-A | Pyridazine compound containing benzo heterocyclic structure, pharmaceutical composition and application thereof | 中国药科大学 | 2024-05-03 | — | — | CN | disclosed |