Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29202242 | 0.83 | LMNA (0.38) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL29202189 | 0.80 | LMNA (0.38) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL30703081 | 0.79 | DRD4 (0.58) | DRD4LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL2706251 | 0.79 | DRD4 (0.58) | DRD4LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL29202211 | 0.72 | LMNA (0.43) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL25319385 | 0.71 | DRD4 (0.46) | DRD4MAPTMMP12BRAF | |
| SCHEMBL29202265 | 0.71 | MEN1 (0.45) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL10703573 | 0.68 | RAB9A (0.57) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4624964 | 0.66 | — | — | |
| SCHEMBL25316878 | 0.66 | DRD4 (0.46) | DRD4MMP12MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964639-A | Pyridazine compound containing benzo heterocyclic structure, pharmaceutical composition and application thereof | 中国药科大学 | 2024-05-03 | — | — | CN | disclosed |