Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CCR9 | P51686 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29208381 | 0.91 | ALDH1A1 (0.56) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL29587490 | 0.91 | ALDH1A1 (0.56) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL29208400 | 0.84 | HDAC8 (0.47) | HDAC10HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL25427265 | 0.84 | ALDH1A1 (0.67) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL24414605 | 0.81 | KDM4E (0.47) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL3274015 | 0.80 | EPHX2 (0.58) | HDAC1EPHX2NAMPTCTSBCTSS | |
| SCHEMBL29208492 | 0.77 | BRD9 (0.44) | HDAC10HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL29588065 | 0.77 | BRD9 (0.44) | HDAC10HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL18664430 | 0.76 | PPARA (0.56) | POLBHDAC1EPHX2NAMPTCTSS | |
| SCHEMBL29208368 | 0.76 | CCNC (0.42) | ALDH1A1KDM4ETSHRHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116391129-A | Target binding assays for RAS proteins | 普罗美加公司 | 2023-07-04 | — | — | CN | disclosed |
| US-20220064696-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | US | disclosed |
| WO-2022047186-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | WO | disclosed |