Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29208492 | 1.00 | BRD9 (0.44) | BRD9BAZ2BBAZ2AHDAC10HDAC6 | |
| SCHEMBL29208400 | 0.92 | HDAC8 (0.47) | BRD9BAZ2BBAZ2AHDAC10HDAC6 | |
| SCHEMBL29208381 | 0.84 | ALDH1A1 (0.56) | BRD9BAZ2BBAZ2AHDAC10HDAC6 | |
| SCHEMBL29587490 | 0.84 | ALDH1A1 (0.56) | BRD9BAZ2BBAZ2AHDAC10HDAC6 | |
| SCHEMBL25421576 | 0.84 | TSHR (0.51) | HDAC10HDAC6KLKB1HDAC8KLK1 | |
| SCHEMBL184953 | 0.82 | GLS (0.54) | GLSBRD4CYP2D6HDAC1ACACB | |
| Hydrochloric Acid SCHEMBL31609012 | 0.81 | GLS (0.53) | GLSBRD4CYP2D6HDAC1ACACB | |
| SCHEMBL24414622 | 0.81 | BRD9 (0.46) | BRD9BAZ2BBAZ2AHDAC10HDAC6 | |
| SCHEMBL24414562 | 0.79 | MTNR1A (0.42) | HDAC6HDAC8HDAC1 | |
| SCHEMBL30991815 | 0.79 | MTNR1A (0.42) | HDAC6HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220064696-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | US | disclosed |
| WO-2022047186-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | WO | disclosed |