Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29208381 | 1.00 | ALDH1A1 (0.56) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL29208475 | 0.91 | ALDH1A1 (0.56) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL25426301 | 0.85 | ALDH1A1 (0.66) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL29208492 | 0.84 | BRD9 (0.44) | BRD9BAZ2BBAZ2AGLSBRD4 | |
| SCHEMBL29588065 | 0.84 | BRD9 (0.44) | BRD9BAZ2BBAZ2AGLSBRD4 | |
| SCHEMBL352314 | 0.80 | ERCC1 (0.52) | GLSBRD4ROCK2CTSBCTSS | |
| SCHEMBL24414605 | 0.79 | KDM4E (0.47) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL29208441 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL29208400 | 0.76 | HDAC8 (0.47) | BRD9BAZ2BBAZ2ABRD4HDAC10 | |
| SCHEMBL25427265 | 0.75 | ALDH1A1 (0.67) | ALDH1A1KDM4ETSHRHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220064696-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | US | disclosed |
| WO-2022047186-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | WO | disclosed |