Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ATP4A | P20648 | 1/20 | 0.44 |
| ▸ | ATP4B | P51164 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921790 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL2913063 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL10747580 | 0.74 | ALDH1A1 (0.69) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL11647465 | 0.73 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL23732252 | 0.73 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL9671945 | 0.71 | ALDH1A1 (1.00) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL1157003 | 0.71 | MAPT (0.65) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL30403242 | 0.70 | ALDH1A1 (0.63) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL29991989 | 0.70 | ALDH1A1 (0.58) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL4876345 | 0.69 | ALDH1A1 (0.76) | ALDH1A1MAPTLMNAL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855288-B2 | Pyrrolo [1,2-d] [1,2-4] triazine as inhibitors of c-Jun N terminal kinases (JNK) and p-38 kinases | NOVARTIS AG (CH) | 2010-12-21 | — | — | US | disclosed |
| EP-1807431-B1 | PYRROLO[1,2-D][1,2-4]TRIAZINE AS INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND P-38 KINASES | NOVARTIS AG (CH) | 2010-09-08 | — | — | EP | disclosed |
| US-20080253988-A1 | Pyrrolo [1,2-D] [1,2-4] Triazine as Inhibitors of C-Jun N Terminal Kinases (Jnk) and P-38 Kinases | NOVARTIS AG (CH) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080253988-A1 | Pyrrolo [1,2-D] [1,2-4] Triazine as Inhibitors of C-Jun N Terminal Kinases (Jnk) and P-38 Kinases | MAPK8, MAP3K8, STK38 | ALDH1A1 3728/4885MAPT 1212/4885LMNA 2697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.