Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.50 |
| ▸ | HPN | P05981 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11465754 | 0.85 | KEAP1 (0.50) | KEAP1NFE2L2HPNFGFR1LMNA | |
| SCHEMBL30923148 | 0.82 | HTT (0.68) | KEAP1NFE2L2HPNLMNATSHR | |
| SCHEMBL20501067 | 0.82 | HTT (0.68) | KEAP1NFE2L2HPNLMNATSHR | |
| SCHEMBL28558155 | 0.81 | HTT (0.66) | LMNAALDH1A1POLBMEN1MAPT | |
| SCHEMBL19657952 | 0.78 | KEAP1 (0.56) | KEAP1NFE2L2ALDH1A1POLBMEN1 | |
| SCHEMBL28287787 | 0.78 | HPN (0.49) | KEAP1NFE2L2HPNFGFR1LMNA | |
| SCHEMBL16062208 | 0.78 | TP53 (0.49) | KEAP1NFE2L2HPNLMNATSHR | |
| SCHEMBL3929733 | 0.75 | GRM5 (0.58) | KEAP1NFE2L2HPNFGFR1ALDH1A1 | |
| SCHEMBL23733403 | 0.75 | FAAH (0.43) | KEAP1NFE2L2TSHRALDH1A1POLB | |
| SCHEMBL2643542 | 0.75 | KEAP1 (0.52) | KEAP1NFE2L2HPNFGFR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |