Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.60 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.59 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.59 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.59 |
| ▸ | KRAS | P01116 | 2/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | POLG | P54098 | 1/20 | 0.54 |
| ▸ | PNP | P00491 | 1/20 | 0.53 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.49 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.49 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.49 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.49 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.49 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913809 | 1.00 | TGM2 (0.62) | TGM2POLBFUT5P2RY6P2RY2 | |
| SCHEMBL25712474 | 1.00 | TGM2 (0.62) | TGM2POLBFUT5P2RY6P2RY2 | |
| Deoxy Adenosinediphosphate SCHEMBL5827743 | 0.99 | TGM2 (0.63) | TGM2POLBFUT5P2RY6P2RY2 | |
| Deoxy Adenosinediphosphate SCHEMBL5827749 | 0.99 | TGM2 (0.63) | TGM2POLBFUT5P2RY6P2RY2 | |
| SCHEMBL20442307 | 0.92 | POLB (0.61) | TGM2POLBFUT5P2RY6P2RY2 | |
| SCHEMBL2922052 | 0.92 | POLB (0.61) | TGM2POLBFUT5P2RY6P2RY2 | |
| SCHEMBL5334255 | 0.91 | FUT5 (0.58) | TGM2POLBFUT5P2RY6P2RY2 | |
| SCHEMBL23584319 | 0.90 | FUT5 (0.64) | TGM2POLBFUT5P2RY6P2RY2 | |
| SCHEMBL4380341 | 0.90 | TGM2 (0.51) | TGM2POLBFUT5P2RY6P2RY2 | |
| SCHEMBL15833359 | 0.90 | FUT5 (0.64) | TGM2POLBFUT5P2RY6P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4398254-A2 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | Memorial Sloan Kettering Cancer Center (US) | 2024-07-10 | — | — | EP | disclosed |
| EP-2991655-B1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2024-04-10 | — | — | EP | disclosed |
| US-11014956-B2 | Compositions and methods for altering second messenger signaling | Memorial Sloan Kettering Cancer Center; The Rockefeller (US) | 2021-05-25 | — | — | US | disclosed |
| CN-112386604-A | Modulators of cGAS | 纪念斯隆-凯特琳癌症中心 | 2021-02-23 | — | — | CN | disclosed |
| US-20190330257-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | MEMORIAL SLOAN KETTERING CANCER CENTER | 2019-10-31 | — | — | US | disclosed |
| US-10385091-B2 | Compositions and methods for altering second messenger signaling | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2019-08-20 | — | — | US | disclosed |
| US-10131686-B2 | Compositions and methods for altering second messenger signaling | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2018-11-20 | — | — | US | disclosed |
| US-20180127454-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2018-05-10 | — | — | US | disclosed |
| US-20180118777-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | MEMORIAL SLOAN KETTERING CANCER CENTER | 2018-05-03 | — | — | US | disclosed |
| US-9840533-B2 | Compositions and methods for altering second messenger signaling | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2017-12-12 | — | — | US | disclosed |
| US-20160068560-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2016-03-10 | — | — | US | disclosed |
| EP-2991655-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | Memorial Sloan Kettering Cancer Center (US) | 2016-03-09 | — | — | EP | disclosed |
| WO-2014179335-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2014-11-06 | — | — | WO | disclosed |
| EP-0978569-B1 | METHOD OF DNA SEQUENCING | RIKAGAKU KENKYUSHO (JP) | 2004-09-22 | — | — | EP | disclosed |
| US-6365350-B1 | REACTING RIBONUCLEOTIDE 5'-TRIPHOSPHATES AND 3'-DEOXY NUCLEOTIDE TRIPHOSPHATES WITH RNA POLYMERASE AND DNA FRAGMENT CONTAINING A PROMOTER SEQUENCE FOR THE POLYMERASE, THEN SEPARATING THE TRANSCRIPTION PRODUCT AND SEQUENCING IT | THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH (JP) | 2002-04-02 | — | — | US | disclosed |
| US-6265569-B1 | HAS ALKYL LINKER INCLUDING DOUBLE OR TRIPLE BOND WHICH ATTACHES FLUORESCENT MOLECULE TO NUCLEOTIDE; FOR TERMINATORS IN DNA SEQUENCING USING RNA POLYMERASES | THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-1046648-A1 | 3'-DEOXYRIBONUCLEOTIDE DERIVATIVES | THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH (JP) | 2000-10-25 | — | — | EP | disclosed |
| EP-0978569-A1 | METHOD OF DNA SEQUENCING | THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH (JP) | 2000-02-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127454-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | CGAS, PDE7A, PRKG1 | TGM2 1071/4885POLB 381/4885FUT5 4827/4885 |
| US-11014956-B2 | Compositions and methods for altering second messenger signaling | NT5C2, PLA2G4B, PLA2G4C | TGM2 2830/4885POLB 508/4885FUT5 4530/4885 |
| US-20190330257-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | CGAS, PDE7A, PRKG1 | TGM2 1071/4885POLB 381/4885FUT5 4827/4885 |
| US-20160068560-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | CGAS, PDE7A, PRKG1 | TGM2 1071/4885POLB 381/4885FUT5 4827/4885 |
| US-10385091-B2 | Compositions and methods for altering second messenger signaling | CGAS, PDE7A, PRKG1 | TGM2 1071/4885POLB 381/4885FUT5 4827/4885 |
| US-10131686-B2 | Compositions and methods for altering second messenger signaling | CGAS, PDE7A, PRKG1 | TGM2 1071/4885POLB 381/4885FUT5 4827/4885 |
| US-20180118777-A1 | COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING | CGAS, PDE7A, PRKG1 | TGM2 1071/4885POLB 381/4885FUT5 4827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.